ArticleCommunications biology2026
Diurnal choroid plexus function in mice depends on sex, age, and amyloid-β status.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Circadian control of immune homeostasis in cardiovascular health and disease.Frontiers in immunology · 2026Review
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Authors and funding
12 authors.
Funding
Abstract
The adult choroid plexus (ChP) produces the majority of cerebrospinal fluid (CSF), yet little is known about the biological and physiological factors that regulate the ChP under healthy conditions. CSF physiology is regulated by sleep and/or time of day and alters with age and in Alzheimer's disease (AD), where sleep and circadian disruption often co-occur. We compare the transcriptome from mouse ChP in three conditions (young, aged, aged with amyloid β (Aβ) pathology) collected at day and night. In young mice, diurnal ChP gene expression changes are reflected in ontology pathways for protein stability and cell metabolism. In aged mice, these pathways shift to membrane transport and ion homeostasis, with diurnal regulation lost with Aβ pathology. ChP protein expression of ion co-transporter NKCC1 varies across diurnal timepoints with both age and sex and accompanies changes in CSF [K
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