Evidence map›Paper›PMID 42162343›Full record

ArticleCell death and differentiation2026

Arginine Di-methylation of RIP3 safeguards necroptosis for intestinal homeostasis.

Pan Zhao, Hanjun Dan, Yazhou Wang, Xin Chen, Xiangling Jiang, Yao Shen, Dan Feng, Jiajia Wang, Zhiwei Yang, Jiasheng Zhao and 5 more

Abstract read
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In one paragraph

Article in Cell death and differentiation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Pan Zhao *State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Hanjun Dan *State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yazhou WangDepartment of Neurobiology and Institute of Neurosciences, School of Basic Medicine, Fourth Military Medical University, Xi'an, Shaanxi, China.ORCID http://orcid.org/0000-0002-7116-2395
Xin ChenState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.ORCID http://orcid.org/0000-0002-2477-6087
Xiangling JiangState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.
Yao ShenState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Dan FengState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Jiajia WangState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Zhiwei YangMOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiao tong University, Xi'an, China.ORCID http://orcid.org/0000-0001-6969-8177
Jiasheng ZhaoMOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, School of Physics, Xi'an Jiao tong University, Xi'an, China.
Yingying ZhangState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, China.ORCID http://orcid.org/0000-0003-0936-7776
Mengying WeiState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China.
Jianyong ZhengState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Department of Digestive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, China.ORCID http://orcid.org/0000-0001-9085-3696
Wen LiuState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Fujian, China.ORCID http://orcid.org/0000-0003-3434-4162
Jian ZhangState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, China. biozhangj@fmmu.edu.cn.ORCID http://orcid.org/0000-0001-9129-9092

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82372960
6 · The paper itself

Abstract

Necroptosis, driven by RIP3, is critical for intestinal homeostasis but requires stringent regulation to prevent inflammatory pathology. While inhibitory checkpoints of RIP3 are known, mechanisms enabling its physiological activation remain unclear. We identify PRMT5-mediated symmetric di-methylation of RIP3 at arginine 479 (R479) serves as a gatekeeper specifically suppresses RIP1- but not ZBP1- driven necroptosis in intestinal epithelial cells (IECs). Notably, even though STORM super-resolution imaging and molecular dynamics simulations revealed that R479 methylation adjacent to the RHIM domain sterically blocks RIP3 oligomerization both with RIP1 and ZBP1. Mice harboring IEC-specific Rip3

Identifiers

PMID42162343

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.