ArticleNpj viruses2026
CCHFV GP38 and GP85 interact with cell-surface glycosaminoglycans.
Article in Npj viruses, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
Abstract
Crimean Congo Hemorrhagic Fever Virus (CCHFV) is a negative-strand segmented RNA virus responsible for severe hemorrhagic fever in humans. The M genomic segment of CCHFV encodes a polyprotein precursor that is processed by cellular proteases into several structural and non-structural proteins. Among them, GP38 and its precursor GP85 are known to be secreted into the extracellular environment. We investigated their abilities to bind cells and we identified that they strongly bind to the cell plasma membrane through interaction with glycosaminoglycans (GAGs). This interaction was mapped to a surface-exposed basic cluster that combines both a prototypical GAG-binding domain and linearly distant amino acids. The present study describes for the first time the interaction between CCHFV GP38/85 proteins and host cell GAGs and characterizes the interaction domain.
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Registered trials
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