Evidence map›Paper›PMID 42162244›Full record

ArticleCommunications biology2026

Enhanced expression of spinal PTP1B contributes to peripheral inflammation- induced glycinergic disinhibition and mechanical pain.

Hu-Hu Bai, Xue Bai, Xiao-Xue Liu, Yu-Bo Gao, Juan Li, Xu Yang, Jia-Ning Dang, Ying Wang, Yu-Xuan Zhang, Zhi-Yang Zhang and 4 more

Abstract read
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In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hu-Hu Bai *Department of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu, PR China.
Xue Bai *Department of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu, PR China.
Xiao-Xue Liu *Department of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu, PR China.
Yu-Bo GaoDepartment of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu, PR China.
Juan LiDepartment of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu, PR China.
Xu YangDepartment of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu, PR China.
Jia-Ning DangDepartment of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu, PR China.
Ying WangDepartment of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu, PR China.
Yu-Xuan ZhangDepartment of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu, PR China.
Zhi-Yang ZhangDepartment of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu, PR China.
Qi ZhangDepartment of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu, PR China.
Yan-Ni LiuDepartment of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu, PR China.
Jiang-Ping LiuNHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Institute of Clinical Research and Translational Medicine, Gansu Provincial Hospital, Lanzhou, Gansu, China.
Zhan-Wei SuoDepartment of Molecular Pharmacology, School of Pharmacy, Lanzhou University, Lanzhou, Gansu, PR China. suozhw@lzu.edu.cn.ORCID http://orcid.org/0000-0001-7141-6597

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal glycinergic disinhibition represents an important contributor to mechanical pain hypersensitivity. However, the molecular mechanisms through which peripheral inflammation induces glycinergic disinhibition remain incompletely understood. Here we show that the protein tyrosine phosphatase-1B (PTP1B) is present at inhibitory synapses of spinal somatostatin-positive (SOM

Indexed as

GlycineInflammationPainProtein Tyrosine Phosphatase, Non-Receptor Type 1Spinal CordAnimalsInterneuronsMaleMiceReceptors, GlycineReceptors, G-Protein-CoupledGlycineProtein Tyrosine Phosphatase, Non-Receptor Type 1Ptpn1 protein, mouseReceptors, GlycineReceptors, G-Protein-Coupled

Identifiers

PMID42162244
PMCPMC13458505

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.