Evidence map›Paper›PMID 42162228›Full record

ArticleCommunications biology2026

Structural basis of the sweat odorant HMHA recognition by the human odorant receptor OR52E8.

Chulwon Choi, Hyeonsung Byeon, Juho Lee, Hong Geun Lee, Chaok Seok, Hee-Jung Choi

Abstract read
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chulwon ChoiDepartment of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
Hyeonsung ByeonDepartment of Chemistry, Seoul National University, Seoul, Republic of Korea.ORCID http://orcid.org/0009-0009-5622-2175
Juho LeeDepartment of Chemistry, Seoul National University, Seoul, Republic of Korea.
Hong Geun LeeDepartment of Chemistry, Seoul National University, Seoul, Republic of Korea.
Chaok SeokDepartment of Chemistry, Seoul National University, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-1419-9888
Hee-Jung ChoiDepartment of Biological Sciences, Seoul National University, Seoul, Republic of Korea. choihj@snu.ac.kr.ORCID http://orcid.org/0000-0002-1167-1526

Funding

National Research Foundation of Korea (NRF) 2023R1A2C3004205National Research Foundation of Korea (NRF) RS-2024-00344154National Research Foundation of Korea (NRF) RS-2024-00407331National Research Foundation of Korea (NRF) RS-2024-00440289Seoul National University AI-Bio Research Grant
6 · The paper itself

Abstract

3-Hydroxy-3-methyl hexanoic acid (HMHA), a key component of human axillary sweat, specifically activates the human odorant receptor OR52E8. However, the molecular basis of this recognition remains elusive. A recent structural study of an odorant-bound consensus OR52 (OR52

Indexed as

CaproatesOdorantsReceptors, OdorantSweatBinding SitesCryoelectron MicroscopyHumansModels, MolecularProtein BindingProtein ConformationCaproatesReceptors, Odorant

Identifiers

PMID42162228
PMCPMC13458081

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.