ArticleScientific reports2026
Loop dynamics govern MALT1 activation revealed by integrative AlphaFold, MD, and NMR analysis.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a central regulator of immune signalling, yet how its conformational dynamics govern activation remains poorly understood. Here, we integrate NMR relaxation measurements, molecular dynamics simulations, and ensemble modelling to characterise the solution-state behaviour of the catalytic core MALT1(PCASP-Ig3)
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