Evidence map›Paper›PMID 42162179›Full record

ArticleScientific reports2026

SPP1 knockdown inhibits invasion, migration and paclitaxel-induced Epithelial-Mesenchymal Transition in Cervical Cancer Cells through the TGF-β/Akt/Snail pathway.

Qianqian Cao, Yayin Lin, Huiwen Guan, Chunlin Dong, Yunjun Ge, Min Li, Qian Zhang, Shuhui Guo, Mingyu Qin, Jinjin Yu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qianqian Cao *Wuxi School of Medicine, Jiangnan University, Wuxi, 214000, Jiangsu, China.
Yayin Lin *Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, China.
Huiwen GuanWuxi School of Medicine, Jiangnan University, Wuxi, 214000, Jiangsu, China.
Chunlin DongWuxi School of Medicine, Jiangnan University, Wuxi, 214000, Jiangsu, China.
Yunjun GeWuxi School of Medicine, Jiangnan University, Wuxi, 214000, Jiangsu, China.
Min LiDepartment of Tumor, People's Hospital of Maanshan, Maanshan, China.
Qian ZhangWuxi School of Medicine, Jiangnan University, Wuxi, 214000, Jiangsu, China.
Shuhui GuoSchool of Health and Medicine, Wuxi Taihu University, Wuxi, China.
Mingyu QinWuxi School of Medicine, Jiangnan University, Wuxi, 214000, Jiangsu, China.
Jinjin YuWuxi School of Medicine, Jiangnan University, Wuxi, 214000, Jiangsu, China. 9812015208@jiangnan.edu.cn.
Guosheng WuWuxi School of Medicine, Jiangnan University, Wuxi, 214000, Jiangsu, China. 8878700009@jiangnan.edu.cn.

Funding

Anhui Provincial Health Research Program for Young Scientists No. AHWJ2024BAb30003Medical Discipline Development Fund of School of Medicine, Jiangnan University No. YXXK2024092612 and YXXK2024092602National Science Foundation for Young Scientists of China No. 81603158, 82202910
6 · The paper itself

Abstract

Secreted Phosphoprotein 1 (SPP1) was reported to promote the progression of multiple tumors by modulating the immune microenvironment and facilitating metastasis, but its role in cervical cancer remains unclear. Our purpose was to explore the effect and the potential mechanisms of SPP1 on cervical cancer progression and paclitaxel (PTX)-induced epithelial-mesenchymal transition (EMT). The Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) database were used to detect SPP1 expression in human cervical cancer and para-carcinoma non-tumor tissues, immunohistochemistry and western blotting experiments were carried out to confirm the expression of SPP1 in clinical samples. Cancer cell proliferation and metastasis assays were conducted to detect the effects of SPP1 on cancer progress using normal and SPP1-knockdown cervical cancer cells. Transcriptomics data and protein expression assays were utilized to investigate the mechanism underlying the effect of SPP1 on PTX-induced EMT. The mouse metastasis model was used to detect the effect of SPP1 on PTX-induced EMT during cervical cancer metastasis. SPP1 is highly expressed in cervical cancer clinical samples and is associated with low survival rates, SPP1 knockdown inhibits cervical cancer cell migration and invasion but doesn't affect cell proliferation. Further studies revealed that SPP1 knockdown suppresses tumor cell EMT through the TGF-β/Akt/Snail pathway. Both in vivo and in vitro data confirmed that SPP1 knockdown alleviates PTX-induced EMT. SPP1 knockdown inhibits the invasion, metastasis and PTX-induced EMT of cervical cancer by suppressing TGF-β/Akt/Snail signaling pathway, and SPP1 is a potential therapeutic target for cervical cancer treatment.

Indexed as

Epithelial-Mesenchymal TransitionOsteopontinPaclitaxelTransforming Growth Factor betaUterine Cervical NeoplasmsAnimalsAntineoplastic Agents, PhytogenicCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansMiceNeoplasm InvasivenessAntineoplastic Agents, PhytogenicOsteopontinPaclitaxelProto-Oncogene Proteins c-aktSnail Family Transcription FactorsSPP1 protein, humanTransforming Growth Factor betaCervical cancerEMTMetastasisPaclitaxelSPP1

Identifiers

PMID42162179
PMCPMC13392292

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.