Evidence map›Paper›PMID 42162143›Full record

ArticleScientific reports2026

Potential glutamatergic and GABAergic false neurotransmitters in models of excitation-inhibition imbalance.

Amalia Perna, Jing Zhao, Chandresh R Gajera, Marcus Schonemann, Nay L Saw, Mehrdad Shamloo, Kathleen S Montine, Albert W Garofalo, Thomas J Montine

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amalia PernaDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA. amaliap@stanford.edu.
Jing ZhaoDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Chandresh R GajeraDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Marcus SchonemannDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Nay L SawBehavioral and Functional Neuroscience Laboratory, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Mehrdad ShamlooBehavioral and Functional Neuroscience Laboratory, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Kathleen S MontineDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Albert W GarofaloDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Thomas J MontineDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Funding

Animal Research Equipment, Digital Cages & Metabolic, Avoidance, Fear Conditioning, Place Preference, Self-Administration, Open Field, & Microdialysis Systems for Translational NeuroscienceS10OD030452 · OD · STANFORD UNIVERSITY · PI SHAMLOO, MEHRDAD · 2021 to 2021
$743k
Ultra high throughput sequencer for sustaining and enhancing multi-scale genomic studiesS10OD025212 · OD · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2018 to 2018
$600k
Computer ClusterS10OD021763 · OD · STANFORD UNIVERSITY · PI JI, HANLEE P · 2016 to 2016
$481k
NIH HHS S10 OD021763NIH HHS S10 OD025212NIH HHS S10 OD030452
6 · The paper itself

Abstract

We previously determined that 2-Methylglutamate (2MeGlu) and 4-aminopentanoic acid (4APA) have neurochemical properties of glutamatergic and GABAergic false neurotransmitters (FNTs); here, we tested whether their activity impacts mouse models with excitation-inhibition (E-I) imbalance. We first screened racemic agents using models caused by E-I imbalance; rac-2MeGlu, but not rac-4APA, suppressed 81% of excitotoxicity in hippocampal slices and increased survival by 105% in Aldh5a1

Indexed as

gamma-Aminobutyric AcidGlutamic AcidNeurotransmitter AgentsAnimalsDisease Models, AnimalHippocampusHumansMaleMiceMice, Knockoutgamma-Aminobutyric AcidGlutamic AcidNeurotransmitter Agents

Identifiers

PMID42162143
PMCPMC13392449

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.