ArticleScientific reports2026
Effect of ketamine intervention on hemodynamic responses in patients with treatment-resistant depression.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Emerging evidence shows that ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, can produce rapid anti-suicidal effects in treatment-resistant depression, yet its underlying neuropharmacological mechanisms remain elusive. The present study aimed at investigating the therapeutic effect of ketamine infusion on suicidal ideation by examining hemodynamic response changes in resting-state fMRI (rsfMRI) data. We analyzed data from clinical trials involving 45 patients with treatment-resistant depression, including either ketamine (N = 21) or midazolam (N = 24). T1-weighted images and rsfMRI data were collected before and three days after treatment. Three parameters, including response height (RH), time-to-peak (TTP), and full-width at half-maximum (FWHM), were extracted. Results showed that ketamine significantly altered TTP and FWHM in the bilateral olfactory cortex and right inferior parietal gyrus. Changes in TTP and FWHM within the thalamus and superior frontal gyrus were associated with improvements in suicidal ideation. Additionally, ketamine responders exhibited reduced TTP in the left precuneus. These findings suggest that ketamine induces region-specific HRF modulations in brain regions implicated in sensory-cognitive integration, mood regulation, and cognitive control. This supports a broader model in which ketamine's neuropharmacological effects may be understood through the lens of neurovascular coupling dynamics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.