ArticleScientific reports2026
Muscle-specific differences in MyHC isoform abundance, metabolic profile and gene expression in cattle.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscles in cattle exhibit variability in their structural and metabolic features, which are influenced by their anatomical location and function. This study aimed to characterise MyHC isoforms proportions, metabolic profile, adiposity and the expression of genes regulating muscle and lipid traits, and to analyse their interrelationships in two functionally distinct muscles -Longissimus thoracis (LT) and Masseter (MS)- in young Holstein and Pirenaica bulls raised for meat production. Eight young bulls from each group were sampled at the commercial slaughter age. The LT muscle exhibited a high proportion of fast-twitch glycolytic MyHC IIX (~ 47%) and fast-oxidative MyHC IIA (~ 36%) isoforms, whereas the MS contained only slow-oxidative MyHC I isoforms in both groups. Glycolytic enzyme activities were higher and oxidative enzyme activities lower in LT than in MS (P < 0.01). Adipocyte size distribution was unimodal in LT, whereas MS showed a more heterogeneous distribution, with indications of a second population of larger adipocytes. Gene expression of myosin heavy chain 1 (MYH1), myogenic differentiation 1 (MYOD1), and myostatin (MSTN) was significantly higher in LT than in MS muscle. Conversely, myosin heavy chain 7 (MYH7) along with lipoprotein lipase (LPL), fatty acid translocase (CD36) and carnitine palmitoyl transferase 1B (CPT1B), associated with lipid uptake, oxidation and triacylglycerol synthesis, were upregulated in MS in both groups (P < 0.05). Overall, the MS muscle, continuously active due to its role in mastication, showed a slow-twitch oxidative profile and molecular features associated with enhanced lipid metabolism. In contrast, the LT muscle, involved in locomotion, showed a glycolytic phenotype associated with markers of muscle growth and fast fibre differentiation, reflecting muscle-specific traits. These contrasting profiles reflect a physiological specialisation shaped by function and point to a coordinated regulation of structural, metabolic, and molecular traits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.