Evidence map›Paper›PMID 42161995›Full record

ArticleNature communications2026

Cholecystokinin input from the anterior cingulate cortex to the lateral periaqueductal gray mediates nocebo pain behavior in mice.

Sandra J Poulson, Aleksandrina Skvortsova, Fatama Tuz Zahra, Damien C Boorman, Seyed Asaad Karimi, Lisiê V Paz, Wanning Cui, Antonietta Mandatori, Jacob Burek, Zahra Siddiqi and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Sandra J PoulsonDepartment of Psychological and Brain Sciences, University of Toronto Mississauga, Mississauga, ON, Canada.ORCID http://orcid.org/0000-0002-5533-4599
Aleksandrina SkvortsovaDepartment of Psychology, McGill University, Montreal, QC, Canada.
Fatama Tuz ZahraDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0009-0007-4654-4061
Damien C BoormanDepartment of Psychological and Brain Sciences, University of Toronto Mississauga, Mississauga, ON, Canada.
Seyed Asaad KarimiDepartment of Psychological and Brain Sciences, University of Toronto Mississauga, Mississauga, ON, Canada.
Lisiê V PazDepartment of Psychological and Brain Sciences, University of Toronto Mississauga, Mississauga, ON, Canada.
Wanning CuiDepartment of Psychological and Brain Sciences, University of Toronto Mississauga, Mississauga, ON, Canada.
Antonietta MandatoriDepartment of Psychological and Brain Sciences, University of Toronto Mississauga, Mississauga, ON, Canada.ORCID http://orcid.org/0009-0005-0548-896X
Jacob BurekDepartment of Psychological and Brain Sciences, University of Toronto Mississauga, Mississauga, ON, Canada.
Zahra SiddiqiDepartment of Psychological and Brain Sciences, University of Toronto Mississauga, Mississauga, ON, Canada.ORCID http://orcid.org/0009-0001-4762-8140
Maryam I FaziliDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.ORCID http://orcid.org/0009-0008-2697-6104
Shivani R GamiDepartment of Psychological and Brain Sciences, University of Toronto Mississauga, Mississauga, ON, Canada.ORCID http://orcid.org/0009-0005-1248-9362
Oakley B MorganDepartment of Psychology, McGill University, Montreal, QC, Canada.
Mélanie Di MariaDepartment of Psychology, McGill University, Montreal, QC, Canada.
Anton DinhDepartment of Psychological and Brain Sciences, University of Toronto Mississauga, Mississauga, ON, Canada.
Lianfang LiangDepartment of Psychology, McGill University, Montreal, QC, Canada.
Robert ContofalskyDepartment of Psychology, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0009-0005-4907-4144
Jeffrey S MogilDepartment of Psychology, McGill University, Montreal, QC, Canada. jeffrey.mogil@mcgill.ca.ORCID http://orcid.org/0000-0003-1359-5720
Loren J MartinDepartment of Psychological and Brain Sciences, University of Toronto Mississauga, Mississauga, ON, Canada. lj.martin@utoronto.ca.ORCID http://orcid.org/0000-0003-0579-2441

Funding

Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology) RGPIN-2023-05350Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) PJT-189987
6 · The paper itself

Abstract

The nocebo effect, opposite of the better-known placebo effect, in which anticipation of harm worsens pain and other symptoms, is increasingly thought to be responsible for poor clinical outcomes. In humans, nocebo hyperalgesia (i.e., increased pain sensitivity) is blocked by proglumide, a cholecystokinin (CCK) receptor antagonist. Yet, the neural circuitry underlying nocebo hyperalgesia remains unidentified, largely due to a lack of appropriate animal models. Here, we developed distinct mouse models of CCK-dependent nocebo hyperalgesia in which the expectation of pain was elicited by contextual or social cues. We find that these nocebo paradigms share a neural circuit involving CCK release from neurons projecting from the anterior cingulate cortex to the lateral periaqueductal gray. This pathway could represent a promising target for therapeutic interventions in pain-related disorders.

Indexed as

CholecystokininGyrus CinguliHyperalgesiaPainPeriaqueductal GrayAnimalsBehavior, AnimalDisease Models, AnimalMaleMiceMice, Inbred C57BLNeuronsProglumideCholecystokininProglumide

Identifiers

PMID42161995
PMCPMC13381858

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.