Evidence map›Paper›PMID 42161933›Full record

ArticleTranslational psychiatry2026

Xanomeline-trospium reverses phencyclidine-induced cognitive deficits through modulation of the gut microbiota-brain axis in mice.

Xin Ding, Rumi Murayama, Yi Cai, Yong Yue, Jian-Jun Yang, Kenji Hashimoto

Abstract read
In one paragraph

Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xin DingChiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.
Rumi MurayamaChiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.
Yi CaiChiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.
Yong YueChiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan.
Jian-Jun YangDepartment of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China. yjyangjj@126.com.ORCID http://orcid.org/0000-0001-6785-9627
Kenji HashimotoChiba University Center for Forensic Mental Health, Chiba, 260-8670, Japan. hashimoto@faculty.chiba-u.jp.ORCID http://orcid.org/0000-0002-8892-0439

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82171189National Natural Science Foundation of China (National Science Foundation of China) U23A20421
6 · The paper itself

Abstract

Cognitive impairment in schizophrenia remains largely unaddressed by dopamine-based antipsychotics. Xanomeline-trospium (KarXT; Cobenfy

Indexed as

BrainCognitive DysfunctionGastrointestinal MicrobiomeMuscarinic AgonistsPhencyclidinePyridinesThiadiazolesAnimalsBenzilatesDisease Models, AnimalDrug CombinationsDysbiosisMaleMiceMice, Inbred C57BLNortropanesBenzilatesDrug CombinationsMuscarinic AgonistsNortropanesPhencyclidinePyridinesThiadiazolesxanomelinexanomeline, trospium drug combination

Identifiers

PMID42161933
PMCPMC13463001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.