ReviewZhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi2026
[Aggressive NK-cell leukemia with CD5(+)CD10(-) monoclonal B cell lymphocytosis and hemophagocytic lymphohistiocytosis: a case report and literature review].
Review in Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aggressive natural killer (NK) -cell leukemia (ANKL) is a rare hematological malignancy characterized by the abnormal proliferation of NK cells. It progresses rapidly and has a high mortality rate. This article reports the diagnosis and treatment of a rare case of a patient with ANKL and concurrent CD5(+)CD10(-) monoclonal B-cell lymphocytosis and hemophagocytic lymphohistiocytosis (HLH), and the relevant literature was reviewed. The patient was a 73-year-old male who presented with fever and lymphadenopathy in multiple areas without any obvious cause for over 1 month. Laboratory examinations, including bone marrow cell morphology and biopsy, revealed two distinct populations of abnormal cells. Flow cytometry, immunohistochemical staining, and gene testing confirmed the diagnoses of ANKL and CD5(+)CD10(-) monoclonal B-cell lymphocytosis, with concurrent HLH. The patient was initially treated with etoposide and dexamethasone. After receiving three courses of chemotherapy based on pegaspargase and other combination regimens, the patient's condition deteriorated. Resuscitation treatment was ineffective; the patient died due to multiple organ failure.
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