Evidence map›Paper›PMID 42161553›Full record

ArticleBMJ open2026

Intensive weight loss intervention versus usual care for adults with severe and complex obesity: the LightWAY randomised trial protocol.

Sarah Wane, Paul Aveyard, Sabrina Wielsøe, Sofus Christian Larsen, Jadine Scragg, Jane Lindschou, Janus Christian Jakobsen, Janus Engstrøm, Ina Olmer Specht, Ann-Kathrin Lindahl Christiansen and 13 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06321458 (Intensive Weight Loss Intervention Versus Usual Care for Adults With Severe and Complex Obesity), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06321458 naactive not recruitingnot on this map

Intensive Weight Loss Intervention Versus Usual Care for Adults With Severe and Complex Obesity: the LightWAY Randomised Trial: Lighthouse Consortium on Obesity Management (LightCOM) Trial no 3

TypeinterventionalSponsorCarsten DirksenRan2024 to 2048Enrolled605ConditionsObesityArmsIntensive weight loss intervention, Usual care
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Sarah WaneNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England, UK.ORCID http://orcid.org/0000-0002-1766-882X
Paul AveyardNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England, UK.ORCID http://orcid.org/0000-0002-1802-4217
Sabrina WielsøeDepartment of Respiratory Diseases and Endocrinology, Amager and Hvidovre Hospital, Copenhagen University Hospital Hvidovre, Hvidovre, Capital Region of Denmark, Denmark.
Sofus Christian LarsenSection of General Practice and Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark.ORCID http://orcid.org/0000-0002-0838-9378
Jadine ScraggNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England, UK.
Jane LindschouCopenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital Rigshospitalet, Copenhagen, Capital Region of Denmark, Denmark.ORCID http://orcid.org/0000-0002-0891-8129
Janus Christian JakobsenCopenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital Rigshospitalet, Copenhagen, Capital Region of Denmark, Denmark.
Janus EngstrømCopenhagen Trial Unit, Centre for Clinical Intervention Research, Copenhagen University Hospital Rigshospitalet, Copenhagen, Capital Region of Denmark, Denmark.
Ina Olmer SpechtSection of General Practice and Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark.ORCID http://orcid.org/0000-0002-3114-4715
Ann-Kathrin Lindahl ChristiansenSection of General Practice and Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark.ORCID http://orcid.org/0000-0003-3917-9151
Aksel Karl Georg JensenSection of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark.
Thomas BandholmDepartment of Clinical Research, Amager and Hvidovre Hospital, Copenhagen University Hospital Hvidovre, Hvidovre, Capital Region of Denmark, Denmark.ORCID http://orcid.org/0000-0001-6884-1971
Charlotte AlburyNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England, UK.
Gritt OverbeckSection of General Practice and Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark.
Susanne ReventlowSection of General Practice and Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark.ORCID http://orcid.org/0000-0002-4990-142X
Kim Rose OlsenDepartment of Public Health, DaCHE, University of Southern Denmark, Odense, Region Syddanmark, Denmark.
Patrick FahrNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England, UK.
Kirstine Nyvold Bojsen-MøllerDepartment of Respiratory Diseases and Endocrinology, Amager and Hvidovre Hospital, Copenhagen University Hospital Hvidovre, Hvidovre, Capital Region of Denmark, Denmark.ORCID http://orcid.org/0000-0003-1962-5302
Berit Lilienthal HeitmannSection of General Practice and Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark.ORCID http://orcid.org/0000-0002-6809-4504
Frans Boch WaldorffSection of General Practice and Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark.
Sten MadsbadDepartment of Respiratory Diseases and Endocrinology, Amager and Hvidovre Hospital, Copenhagen University Hospital Hvidovre, Hvidovre, Capital Region of Denmark, Denmark.
Carsten DirksenDepartment of Respiratory Diseases and Endocrinology, Amager and Hvidovre Hospital, Copenhagen University Hospital Hvidovre, Hvidovre, Capital Region of Denmark, Denmark.
Susan Ann JebbNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, England, UK susan.jebb@phc.ox.ac.uk.ORCID http://orcid.org/0000-0001-9190-2920

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEffective treatment for clinical obesity is available but is rarely offered by healthcare systems, which often treat complications without treating the underlying cause. The LightWAY trial will investigate the clinical benefits and harms as well as cost-effectiveness of an intensive weight loss intervention compared with existing weight management programmes for people with clinical obesity. METHODS AND ANALYSIS: LightWAY is an investigator-initiated, international, randomised, parallel-group clinical superiority trial with blinded outcome assessment. Six hundred people seeking treatment for clinical obesity (body mass index ≥35 kg/m ETHICS AND DISSEMINATION: Ethical approval was granted in the UK (August 2024, 24/SC/0211) and Denmark (December 2023, H-23065222). Findings will be disseminated through peer-reviewed journals and scientific conferences and to participants in the trial and clinicians. TRIAL REGISTRATION NUMBER: NCT06321458.

Indexed as

ObesityWeight Reduction ProgramsAdultBody Mass IndexCost-Benefit AnalysisCost-Effectiveness AnalysisDenmarkDiet, ReducingEquivalence Trials as TopicFemaleHumansQuality of LifeRandomized Controlled Trials as TopicUnited KingdomWeight LossClinical ProtocolsClinical TrialHEALTH ECONOMICSObesityQuality of Life

Identifiers

PMID42161553
PMCPMC13202135

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.