ArticleNeuron2026
Before synapses are lost: Do endogenous retroviruses drive microglial overpruning in autism spectrum disorders?
Article in Neuron, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
Funding
Abstract
Endogenous retroviruses (ERVs) are epigenetically silenced genomic elements whose reactivation can influence host gene regulation. In this issue of Neuron, Chen et al. identify ERV-derived RNA-DNA hybrids that activate neuronal C4b, driving microglial synaptic overpruning and autism-like behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.