ArticleJACC. Advances2026
Prediction of Post-stenting Lumen Dimensions Using High-Definition Intravascular Ultrasound.
Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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15 authors.
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Abstract
backgroundAccurate prediction of stent-plaque interaction is crucial for optimizing lesion preparation strategies and improving percutaneous coronary intervention outcomes. High-definition intravascular ultrasound (HD IVUS) provides detailed imaging of plaque composition and vessel dimensions, enabling computational modeling to predict post-stenting lumen dimensions.
objectivesThe purpose of this study was to develop and validate a patient-specific HD IVUS-based computational framework for the characterization of coronary plaque components and prediction of post-stenting lumen dimensions.
methodsNine patients underwent HD IVUS and coronary angiography before and after stenting. Using pre-stenting HD IVUS images, plaque components (fibrolipid, fibrous, and calcified tissue) were segmented and reconstructed in 3 dimensions. All procedural steps were simulated computationally, and post-simulation lumen dimensions were compared with the actual post-stenting HD IVUS lumen dimensions.
resultsPredicted and actual lumen dimensions post-stenting demonstrated high agreement. The mean lumen diameter difference was 0.17 mm (+5.5% error), with 95% limits of agreement ranging from -0.26 to 0.60 mm. Agreement was also strong for minimal lumen diameter and minimal in-stent cross-sectional area, with differences of -0.02 mm (95% limits of agreement -0.23 to 0.19 mm) and -0.11 mm
conclusionsWe presented and validated a patient-specific computational simulation framework that uses high-resolution intracoronary imaging of plaque components to precisely predict the lumen dimensions post-stenting.
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