Evidence map›Paper›PMID 42161013›Full record

ArticleBiomaterials advances2026

Investigating FTY720-NF immunomodulation of key lipid, gene, and protein mediators to enhance oral tissue regeneration.

Afra I Toma, Daniel C Shah, Victoria R Duke, Nathan F Chiappa, Keerthi P Chinniampalayam Sekar, Tim Cha, Archana Kamalakar, Levi B Wood, Edward A Botchwey, Nick J Willett and 1 more

Abstract read
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In one paragraph

Article in Biomaterials advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Afra I TomaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA, USA; Department of Pediatrics and Otolaryngology, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Daniel C ShahWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Victoria R DukeDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA.
Nathan F ChiappaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Keerthi P Chinniampalayam SekarDepartment of Pediatrics and Otolaryngology, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Tim ChaDepartment of Pediatrics and Otolaryngology, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Archana KamalakarDepartment of Pediatrics and Otolaryngology, Children's Healthcare of Atlanta, Atlanta, GA, USA.
Levi B WoodWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA, USA; George W. Woodruff School of Mechanical Engineering and Parker H. Petit Institute for Bioengineering, Georgia Institute of Technology, 315 Ferst Dr., Atlanta, GA, 30332, USA.
Edward A BotchweyWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA, USA.
Nick J WillettPhil and Penny Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.
Steven L GoudyWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University, Atlanta, GA, USA; Department of Pediatrics and Otolaryngology, Children's Healthcare of Atlanta, Atlanta, GA, USA. Electronic address: steven.goudy@emory.edu.

Funding

An immunomodulatory approach to improve oral cavity wound healingR01DE028905 · NIDCR · EMORY UNIVERSITY · PI GOUDY, STEVEN L · 2020 to 2024
$2.7M
NIDCR NIH HHS R01 DE028905
6 · The paper itself

Abstract

Oronasal fistula (ONF) formation following cleft palate repair remains a significant clinical challenge, often driven by persistent inflammation, fibrotic remodeling, and insufficient mucosal regeneration. Effective oral wound healing depends on precise immune regulation, particularly by macrophages that coordinate both inflammation resolution and tissue repair. The sphingosine-1-phosphate (S1P) pathway is a key regulator of immune cell function and trafficking, and its modulation through the S1P receptor agonist FTY720 (Fingolimod) offers a promising multifaceted strategy for tissue regeneration. In this study, we investigated the therapeutic effect of FTY720 delivered via nanofibers (FTY720-NF) on macrophage-mediated wound repair using multi-omics profiling and translational in vivo models. Treatment of human macrophages with phosphorylated FTY720 (FTY720P) in vitro induced a shift in cytokine and chemokine secretion toward a pro-regenerative phenotype. Integrated lipidomic and transcriptomic analyses revealed significant remodeling of sphingolipid metabolism and gene expression networks associated with pro-regenerative macrophage phenotypes and inflammation resolution. In a porcine model of oral injury, FTY720-NF treatment accelerated re-epithelialization and improved wound healing outcomes compared to injury-only and platelet-rich plasma (PRP) controls. Together, these findings highlight FTY720-NF as a potential immunotherapeutic approach that possibly reprograms cellular responses and tissue environments to promote oral wound healing.

Indexed as

Fingolimod HydrochlorideImmunomodulationNanofibersRegenerationAnimalsCytokinesHumansMacrophagesSphingosineSwineWound HealingCytokinesFingolimod HydrochlorideSphingosineDrug deliveryFTY720NanofibersOral wound healingOronasal fistulaSphingolipids

Identifiers

PMID42161013
PMCPMC13264490

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.