Evidence map›Paper›PMID 42160697›Full record

ArticleACS infectious diseases2026

Design, Synthesis, and Evaluation of Novel Thiazole-Based Peptidomimetic Compounds as Potent SARS-CoV-2 Main Protease Covalent Inhibitors.

Weile Yin, Wai-Po Kong, Siu-Lun Leung, Zhiguang Liang, Yu Wai Chen, Kwok-Yin Wong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Weile YinDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Wai-Po KongDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.ORCID 0000-0002-7245-5149
Siu-Lun LeungDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Zhiguang LiangDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Yu Wai ChenDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.
Kwok-Yin WongDepartment of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China.ORCID 0000-0003-4984-7109

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main protease (M

Indexed as

Antiviral AgentsBetacoronavirusCoronavirus 3C ProteasesPeptidomimeticsProtease InhibitorsSARS-CoV-2ThiazolesAnimalsAzabicyclo CompoundsChlorocebus aethiopsDrug DesignHumansMolecular Docking SimulationPyrrolidinonesStructure-Activity RelationshipVero CellsAntiviral AgentsAzabicyclo CompoundsCoronavirus 3C ProteasesnirmatrelvirPeptidomimeticsProtease InhibitorsPyrrolidinonesThiazolescovalent inhibitorspeptidomimetic inhibitorsSARS-CoV-2 Mprostructure−activity relationshipthiazole-based compounds

Identifiers

PMID42160697
PMCPMC13270522

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.