Evidence map›Paper›PMID 42160518›Full record

ArticleInternational journal of epidemiology2026

Low-dose radiation exposure and risk of self-reported cataract in Fukushima nuclear emergency workers.

Huan Hu, Natsuko Hatsusaka, Mark P Little, Osamu Kurihara, Eunjoo Kim, Hiroshi Sasaki, Tetsuya Mizoue, Toshiteru Okubo

Abstract read
In one paragraph

Article in International journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huan HuResearch Center for Prevention from Radiation Hazards of Workers, National Institute of Occupational Safety and Health, Kanagawa 214-8585, Japan.ORCID 0000-0001-8558-2895
Natsuko HatsusakaDepartment of Ophthalmology, Kanazawa Medical University, Ishikawa 920-0293, Japan.
Mark P LittleFaculty of Health, Science and Technology, Oxford Brookes University, Oxford OX3 0BP, United Kingdom.
Osamu KuriharaDepartment of Radiation Measurement and Dose Assessment, Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.ORCID 0000-0001-9905-9026
Eunjoo KimDepartment of Radiation Measurement and Dose Assessment, Institute of Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.ORCID 0000-0001-9339-8705
Hiroshi SasakiDepartment of Ophthalmology, Kanazawa Medical University, Ishikawa 920-0293, Japan.
Tetsuya MizoueResearch Center for Prevention from Radiation Hazards of Workers, National Institute of Occupational Safety and Health, Kanagawa 214-8585, Japan.
Toshiteru OkuboResearch Center for Prevention from Radiation Hazards of Workers, National Institute of Occupational Safety and Health, Kanagawa 214-8585, Japan.

Funding

Industrial Disease Clinical Research 14090101-01Industrial Disease Clinical Research 190702-01Industrial Disease Clinical Research 240601-01Ministry of Health, Labour and Welfare of Japan
6 · The paper itself

Abstract

backgroundCataract is a well-established radiogenic condition and recent evidence suggests an increased risk even at radiation doses of <100 mGy. Following the 2011 Fukushima Daiichi Nuclear Power Plant accident, ∼20 000 workers participated in emergency operations. This study aimed to investigate the association between cumulative low-dose occupational radiation exposure and the risk of cataract among workers enrolled in the Epidemiological Study of Health Effects in Fukushima Nuclear Emergency Workers.

methodsData from 5773 nuclear emergency workers participating in the cohort were analysed. The cumulative lifetime occupational radiation dose was estimated by combining pre-2011 individual dose records from a nationwide nuclear radiation worker dose registry with radiation doses received during the 2011 emergency-work period. Self-reported, physician-diagnosed cataract was identified through baseline and first follow-up questionnaires. A Cox proportional hazards model was applied to estimate hazard ratios (HRs) with 95% confidence intervals (CIs) for incident cataract, with adjustments for major covariates.

resultsMore than 90% of the participants had cumulative occupational radiation exposure of <100 mSv, including doses received both prior to the accident and during the emergency period (March-November 2011). During 52 921 person-years of follow-up from 2012 to 2024 (mean, 9.2 years), 310 participants reported new-onset cataract. The risk of cataract increased with lifetime occupational exposure up to November 2011, with an HR of 1.03 per 10-mSv increase (95% CI, 1.02, 1.05). This association persisted after excluding participants with doses of ≥100 mSv. For exposure during the emergency period (March-November 2011), the HR was 1.06 per 10-mSv increase (95% CI, 1.03, 1.09). When the cumulative lifetime occupational radiation dose was recalculated by using 2-year and 5-year lag periods before diagnosis or censoring, the HRs per 10-mSv increase were 1.03 (95% CI, 1.01, 1.04) and 1.01 (95% CI, 0.99, 1.04), respectively.

conclusionThis study suggests an excess risk of cataract at doses of <100 mSv and adds to the evidence base suggesting an association between low-dose occupational radiation exposure and cataract risk.

Indexed as

CataractFukushima Nuclear AccidentOccupational DiseasesOccupational ExposureRadiation ExposureAdultFemaleHumansIncidenceJapanMaleMiddle AgedPower Plant OperatorsProportional Hazards ModelsRadiation DosageRisk Factorscataract riskFukushima Daiichi nuclear accidentlow-dose radiationnuclear emergency workers

Identifiers

PMID42160518
PMCPMC13188973

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.