Evidence map›Paper›PMID 42160513›Full record

ArticleMolecular biology of the cell2026

The scaffold protein PRR14L is linked to mitotic fidelity and sensitivity to MPS1 inhibition.

Albert Z Liu, Akshay Narkar, Keming Li, Thierry Bertomeu, Blake A Johnson, Jasmin Coulombe-Huntington, Yi Dong, Jin Zhu, Mike Tyers, Rong Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Albert Z LiuDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-9387-0878
Akshay NarkarDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205.
Keming LiMechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.
Thierry BertomeuThe ChemoGenix CRISPR screening facility of the Institute for Research in Immunology and Cancer, University of Montreal, 2950 Chemin de Polytechnique, Montréal, QC H3T 1J4, Canada.
Blake A JohnsonDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205.
Jasmin Coulombe-HuntingtonDepartment of Bioengineering, McGill University, Montreal, QC H3A 0E9, Canada.
Yi DongDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205.
Jin ZhuMechanobiology Institute, National University of Singapore, Singapore 117411, Singapore.
Mike TyersDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Rong LiDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aneuploidy is a hallmark of cancer and is a potential vulnerability that can be selectively targeted. To systematically identify genes that affect the incidence and fitness of aneuploid cells, we conducted a genome-wide CRISPR/Cas9 screen using NMS-P715, an inhibitor of the spindle assembly checkpoint (SAC) kinase MPS1/TTK. In this study, we identified several genes known to regulate aneuploidy and mitosis, and subsequently focused on

Indexed as

Cell Cycle ProteinsMitosisProtein Serine-Threonine KinasesAneuploidyHumansMicrotubule-Associated ProteinsMicrotubulesM Phase Cell Cycle CheckpointsProtein Phosphatase 2Protein-Tyrosine KinasesSpindle ApparatusCell Cycle ProteinsMicrotubule-Associated ProteinsProtein Phosphatase 2Protein Serine-Threonine KinasesProtein-Tyrosine KinasesTACC3 protein, humanTTK protein, human

Identifiers

PMID42160513
PMCPMC13329865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.