Evidence map›Paper›PMID 42160484›Full record

ArticleJournal of cardiovascular electrophysiology2026

Successful Use of Ranolazine in SCN5A p.R222Q-Related Multifocal Ectopic Purkinje-Related Premature Contractions.

Isabella Moreira Gonzalez Fonseca, Anna Terra França, André Assis Lopes do Carmo, Saskia N van der Crabben, Christian van der Werf, Arthur A M Wilde

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Isabella Moreira Gonzalez FonsecaHospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID 0009-0000-8450-4246
Anna Terra FrançaHospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.ORCID 0009-0007-5363-1681
André Assis Lopes do CarmoHospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Saskia N van der CrabbenDepartment of Clinical Genetics, Amsterdam University Medical Center, Amsterdam, The Netherlands.ORCID 0000-0001-8619-1511
Christian van der WerfDepartment of Cardiology, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands.
Arthur A M WildeDepartment of Cardiology, Amsterdam UMC, Location University of Amsterdam, Amsterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionGain-of-function variants in SCN5A may cause multifocal ectopic Purkinje-related premature contractions (MEPPC), with a high premature ventricular contraction burden that may lead to PVC-induced cardiomyopathy. Pharmacological therapy is usually required, as catheter ablation is ineffective because of the multifocal origin of the ectopy. METHODS AND

resultsWe report two siblings with the pathogenic SCN5A p.Arg222Gln variant. In both, ranolazine markedly suppressed ventricular ectopy, improved or preserved left ventricular function, and enabled amiodarone withdrawal.

conclusionRanolazine may represent a useful mechanism-guided option for SCN5A-related MEPPC.

Indexed as

Anti-Arrhythmia AgentsHeart RateNAV1.5 Voltage-Gated Sodium ChannelPurkinje FibersRanolazineVentricular Premature ComplexesAction PotentialsFemaleGenetic Predisposition to DiseaseHumansMalePedigreePhenotypeTreatment OutcomeAnti-Arrhythmia AgentsNAV1.5 Voltage-Gated Sodium ChannelRanolazineSCN5A protein, humaninherited arrhythmia syndromelate sodium current inhibitionmultifocal ectopic Purkinje‐related premature contractionsranolazineSCN5A

Identifiers

PMID42160484
PMCPMC13372430

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.