Evidence map›Paper›PMID 42160474›Full record

ArticleAmerican journal of physiology. Renal physiology2026

Effects of proximal tubule NBCe1-A deletion on collecting duct intercalated cell responses to hypokalemia.

Hyun-Wook Lee, Autumn N Harris, Susan M Wall, I David Weiner

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hyun-Wook LeeDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, United States.ORCID 0000-0002-6886-3262
Autumn N HarrisDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, United States.ORCID 0000-0002-2329-3905
Susan M WallRenal Division, Department of Medicine, Emory University College of Medicine, Atlanta, Georgia, United States.ORCID 0000-0003-2786-8849
I David WeinerDivision of Nephrology, Hypertension, and Renal Transplantation, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, United States.ORCID 0000-0002-0046-0600

Funding

OXGR1 in Renal Intercalated Cells, Salt Transport and Diuretic EfficacyR01DK110375 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, SUSAN MARIE WALL · 2017 to 2026
$6.7M
Molecular Mechanisms Regulating Ammonia MetabolismR01DK107798 · NIDDK · UNIVERSITY OF FLORIDA · PI WEINER, I. DAVID · 2016 to 2025
$3.2M
Sex Differences in Renal Ammonia MetabolismK08DK120873 · NIDDK · UNIVERSITY OF FLORIDA · PI HARRIS, AUTUMN N · 2019 to 2023
$952k
HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) K08-DK120873HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) R01-107798HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) R01-DK110375NIDDK NIH HHS K08 DK120873NIDDK NIH HHS R01 DK107798NIDDK NIH HHS R01 DK110375
6 · The paper itself

Abstract

Hypokalemia activates intercalated cell acid secretion, but because hypokalemia is typically associated with metabolic alkalosis, this activation cannot be ascribed to extracellular pH. Metabolic acidosis induces responses similar to those of hypokalemia, and its effects are blocked by deletion of the proximal tubule Na

Indexed as

HypokalemiaKidney Tubules, CollectingKidney Tubules, ProximalSodium-Bicarbonate SymportersAcidosisAmmoniaAnimalsHydrogen-Ion ConcentrationMaleMiceMice, Inbred C57BLMice, KnockoutPotassiumSulfate TransportersAmmoniaPotassiumSodium-Bicarbonate SymportersSulfate Transportersacid-basecollecting ductintercalated cellpotassium

Identifiers

PMID42160474
PMCPMC13274494

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.