Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
16 authors.
Olha MelnykDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-9085-6299
Charanya MuralidharanDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-4909-7056
Bryce E DuffettDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0009-0003-3715-6033
Alissa N MuncyDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Leslie E WagnerDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-7821-8809
Matthew AustinDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-8920-4311
Jahnavi AluriIndiana Biosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Abdul S QadirIndiana Biosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-8260-3862
Yashaswini BattinaDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Rachael MoraraDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0009-0007-3879-4474
Glorian Perez-AvilesDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-7892-7645
Justin J CrowderDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0009-0004-6327-6888
Michelle M Martinez-IrizarryDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-5995-9281
Sylvaine YouIndiana Biosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-1578-5205
Roberto MalloneIndiana Biosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-9846-8861
Amelia K LinnemannDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-7356-4876
Funding
The Human Islet Distribution Coordinating Center (UC4)UC4DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI EVANS-MOLINA, CARMELLA, NILAND, JOYCE CAROL · 2012 to 2017
$25.6M
Integrated Islet Distribution Program (U24) - 2021U24DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Carmella Evans-Molina, Joyce Carol Niland · 2021 to 2026
$17.8M
Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
Autophagy/antioxidant response coupling in pancreatic beta-cell homeostasis regulationR01DK124380 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI LINNEMANN, AMELIA K · 2021 to 2025
$2.0M
Functional and molecular characterization of the human islet interferon alpha responseR03DK127766 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI LINNEMANN, AMELIA K · 2020 to 2021
Autophagy, a vital catabolic process, plays a crucial role in maintaining pancreatic β cell function and is disrupted in established type 1 diabetes. However, it is unclear when and how this critical cell process becomes defective during type 1 diabetes pathogenesis. To study the nature of autophagy dysfunction in the context of autoimmune diabetes, we used real-time intravital microscopy to study autophagic flux in vivo. We generated an AAV8-packaged mCherry-eGFP-LC3B biosensor driven by the insulin promoter for β cell-selective expression. For real-time autophagic flux evaluation, fluorescent signals from eGFP and mCherry fluorophores were correlated in space and time to follow the process of autophagosome-lysosome fusion. We observed autophagic flux defects in the β cells of the nonobese diabetic (NOD) mouse model of type 1 diabetes before hyperglycemia onset at both baseline and in response to interferon-α. These defects were still present, although less apparent, in immunodeficient NOD/
Indexed as
AutophagyDiabetes Mellitus, Type 1Insulin-Secreting CellsAnimalsGreen Fluorescent ProteinsHumansIslets of Langerhans TransplantationMiceMice, Inbred NODMice, SCIDGreen Fluorescent Proteins
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Real-time in vivo analysis of murine β cells reveals autophagic flux defects before onset of autoimmune diabetes. · full record | OpenQuestion