Evidence map›Paper›PMID 42160388›Full record

ArticleeLife2026

MORC2 mediates transcriptional regulation through liquid-liquid phase separation.

Yanshen Zhang, Weiya Xu, Wenxiu Duan, Yu Wei, Wenli Jiang, Feng Zhu, Chengdong Huang, Chao Wang, Yihui Bi

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanshen Zhang *Hefei National Research Center for Physical Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID https://orcid.org/0000-0001-8046-0389
Weiya Xu *Hefei National Research Center for Physical Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID https://orcid.org/0000-0001-5796-8758
Wenxiu Duan *Hefei National Research Center for Physical Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Yu WeiHefei National Research Center for Physical Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Wenli JiangHefei National Research Center for Physical Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Feng ZhuHefei National Research Center for Physical Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Chengdong HuangHefei National Research Center for Physical Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID https://orcid.org/0000-0002-8997-9459
Chao WangHefei National Research Center for Physical Sciences at the Microscale, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.ORCID https://orcid.org/0000-0003-3192-2780
Yihui BiDepartment of Orthopedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0009-0000-5486-9009

Funding

Anhui Medical University Foundation 9101224201Center for Advanced Interdisciplinary Science and Biomedicine of IHM QYPY20220014Major Frontier Research Project of USTC LS9100000002National Key Research and Development Program of China 2019YFA0508402National Natural Science Foundation Incubation Program of The Second Affiliated Hospital of Anhui Medical University 2021GQFY02National Natural Science Foundation of China 22122703National Natural Science Foundation of China 31971144National Natural Science Foundation of China 32170767National Natural Science Foundation of China 32470808National Natural Science Foundation of China 32471273National Natural Science Foundation of China T2221005Strategic Priority Research Program of the Chinese Academy of Sciences XDB0490000USTC Research Funds of Double First-Class Initiative YD9100002507
6 · The paper itself

Abstract

MORC2 is a chromatin-associated ATPase essential for transcriptional silencing and genome stability, yet the biophysical principles governing its regulatory activity remain elusive. Here, we demonstrate that full-length MORC2 undergoes biomolecular condensation to form dynamic nuclear assemblies, a process fundamentally required for its repressor function. Endogenous MORC2 forms discrete, dynamic condensates in neurons from

Indexed as

Gene Expression RegulationTranscription FactorsTranscription, GeneticAnimalsBiomolecular CondensatesHumansMiceNeuronsPhase SeparationTranscription Factorsbiochemistrychemical biologychromosomesgene expressionhumanintrinsically disordered regionMORC2neuropathic mutationsnuclear condensatesphase separationtranscriptional regulation

Identifiers

PMID42160388
PMCPMC13189624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.