Evidence map›Paper›PMID 42160204›Full record

ArticleJournal of pediatric hematology/oncology2026

A Rare Case of Homozygous HbE With Coinherited Alpha-Thalassemia and Hb Constant Spring in a Neonate Reveals a Mild Hematologic Phenotype.

Victor Bobée, Maïssa Souissi, Cécile Dumesnil, Thibault Plouchart, Serge Pissard, Frédéric Galacteros, Stéphane Moutereau

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric hematology/oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Victor BobéeDepartment of Biological Hematology, Rouen University Hospital, Rouen.ORCID 0000-0002-9357-4542
Maïssa SouissiDepartment of Biological Hematology, Rouen University Hospital, Rouen.
Cécile DumesnilPediatric Onco-Hematology, Rouen University Hospital, Rouen.
Thibault PlouchartNeonatal Pediatrics, Intensive Care and Neuropediatrics, Rouen University Hospital, Rouen.
Serge PissardGenetics Department, GHU Henri Mondor-APHP.
Frédéric GalacterosDepartment of Biochemistry, GHU Henri Mondor-APHP, Université Paris-Est (UPEC), Créteil, France.
Stéphane MoutereauDepartment of Biochemistry, GHU Henri Mondor-APHP, Université Paris-Est (UPEC), Créteil, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeonatal microcytosis may reveal complex hemoglobinopathy combinations requiring molecular clarification. OBSERVATION: We describe a neonate with homozygous HbE coinherited with α-thalassemia (-3.7 kb deletion) and Hb Constant Spring on the other allele. At birth, marked microcytosis with mild anemia prompted haemoglobin analysis. Despite initial concerns raised by the multiple hemoglobin gene anomalies, follow-up remained asymptomatic, with persistent microcytosis and relative erythrocytosis. Family screening showed that both parents had HbAE. The father carried Hb Constant Spring and the -3.7 deletion, enabling genotype-phenotype correlations.

conclusionSystematic investigation of neonatal microcytosis can identify rare compound disorders and support tailored follow-up.

Indexed as

alpha-ThalassemiaHemoglobins, AbnormalHomozygoteHumansInfant, NewbornPhenotypeHemoglobin Constant SpringHemoglobins, AbnormalanemiahemoglobinopathyRBC pathologythalassemia

Identifiers

PMID42160204
PMCPMC13281976

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