ArticleAngewandte Chemie (International ed. in English)2026
Highly Selective Bioinspired Peptide Channels for Rapid Water Transport.
Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Innovative water-purification technologies are urgently needed to address the global scarcity of clean water. In nature, aquaporin proteins enable rapid and highly selective water transport across membranes. Replicating their exceptional water flux and ion-rejection capabilities in synthetic systems, however, remains a major challenge. Herein, minimalistic peptide-based water-channels inspired by the conserved aquaporin Asn-Pro-Ala (NPA) motif are reported. These designer peptides are suitably functionalized to enable the formation of water-channels by self-assembly. The crystal structures of these water channels highlight how inward-facing polar groups facilitate water transport, while hydrophobic exteriors enable membrane interactions. Channels derived from functionalized PA dipeptides and a tripeptide NPA analog with a pendant cyano group exhibit exceptional single-channel permeabilities (≈10
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