Evidence map›Paper›PMID 42159884›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

SSR4 Sustains Tertiary Lymphoid Structures by Regulation Quality Control of N-linked Glycosylation During B-cell Differentiation Into Plasmacyte in Colorectal Cancer.

Wei Zhao, Youcai Zhao, Haiyang Li, Bowen Yang, Siyan Lu, Xueting Fu, Caixia Zhang, Yirong Chen, Xiaofeng Bian, Xinghua Ma and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Wei ZhaoDepartment of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Youcai ZhaoDepartment of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Haiyang LiDepartment of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Bowen YangGeneral Clinical Research Center, Nanjing First Hospital, China Pharmaceutical University, Nanjing, Jiangsu, China.
Siyan LuGeneral Clinical Research Center, Nanjing First Hospital, China Pharmaceutical University, Nanjing, Jiangsu, China.
Xueting FuGeneral Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Caixia ZhangGeneral Clinical Research Center, Nanjing First Hospital, China Pharmaceutical University, Nanjing, Jiangsu, China.
Yirong ChenGeneral Clinical Research Center, Nanjing First Hospital, China Pharmaceutical University, Nanjing, Jiangsu, China.
Xiaofeng BianGeneral Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Xinghua MaGeneral Clinical Research Center, Nanjing First Hospital, China Pharmaceutical University, Nanjing, Jiangsu, China.
Xiaobing YangDepartment of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Bin WangDepartment of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Yuan FangDepartment of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Lulu YangDepartment of Pathology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Yelin ZhaoDivision of ENT Diseases, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.
Shuli ZhaoGeneral Clinical Research Center, Nanjing First Hospital, China Pharmaceutical University, Nanjing, Jiangsu, China.

Funding

Health Science and Technology Development Key Program of Nanjing zkx22029National Natural Science Foundation of China 82273196National Natural Science Foundation of China 82573062National Natural Science Foundation of Jiangsu Province BK20251731
6 · The paper itself

Abstract

Intratumoral tertiary lymphoid structure (TLS) fosters B-cell differentiation and antibody production, yet the intrinsic programs sustaining these functions remain unclear. By integrating spatial transcriptomics and single-cell RNA sequencing of colorectal cancer, we delineate a B-cell trajectory enriched for endoplasmic reticulum protein processing, autophagy, NF-κB signaling, and N-linked glycosylation, highlighting SSR4 as a progressively induced TRAP-complex component. SSR4 is further upregulated in B cells from anti-PD-1 responders. B-cell-specific Ssr4 deletion leads to peripheral B-cell loss, reduced antibody output, exacerbated colitis, and impaired mucosal immunity. Mechanistically, SSR4 interacts with DDOST to regulate BAFFR N-glycosylation, thereby sustaining B-cell activation and LTα1β2 expression via NF-κB signaling. In Apc

Indexed as

B-LymphocytesColorectal NeoplasmsPlasma CellsTertiary Lymphoid StructuresAnimalsCell DifferentiationGlycosylationHumansMiceB‐cellcolorectal cancerN‐linked glycosylationSSR4tertiary lymphoid structurestumor‐infiltrating B cells (TIBs)

Identifiers

PMID42159884
PMCPMC13336112

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.