Evidence map›Paper›PMID 42159844›Full record

ArticleApplied biochemistry and biotechnology2026

FAM72A Knockdown Drives Cell Mitophagy and Pyroptosis in Ovarian Cancer Via the PINK1/Parkin Pathway.

Songhong Tan, Li Wang, Zhengmei Xu, Rong Tang, Weimin Xie

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Article in Applied biochemistry and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Songhong TanDepartment of Gynecology, Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital, No. 31 Guanghui Road, Zhengxiang District, Hengyang City, Hunan, 421000, China.
Li WangDepartment of Gynecology, Tongren People's Hospital, Tongren, Guizhou, 5543000, China.
Zhengmei XuDepartment of Gynecology, Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital, No. 31 Guanghui Road, Zhengxiang District, Hengyang City, Hunan, 421000, China.
Rong TangDepartment of Gynecology, Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan Province, 421000, China.
Weimin XieDepartment of Gynecology, Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital, No. 31 Guanghui Road, Zhengxiang District, Hengyang City, Hunan, 421000, China. f_199901@163.com.ORCID http://orcid.org/0009-0001-2408-489X

Funding

the Natural Science Foundation of Hunan Province Grant No: 2025JJ80598
6 · The paper itself

Abstract

This study explored the role of Family with Sequence Similarity 72 Member A (FAM72A) in regulating mitophagy and pyroptosis via the PINK1/Parkin pathway in ovarian cancer (OC). Bioinformatics analysis and clinical tissue and cell assays revealed that FAM72A was significantly overexpressed in OC. Silencing FAM72A in OC cells suppressed proliferation, invasion, and migration, while promoting apoptosis. Additionally, FAM72A knockdown increased mitochondrial ROS levels, autophagosome-mitochondria colocalization, and the LC3II/I ratio and reduced p62 expression, mitochondrial membrane potential, and ATP levels in OC cells. Downregulation of FAM72A upregulated PINK1 and Parkin expression and increased the expression of pyroptosis-related markers including NLRP3, ASC, cleaved caspase-1, IL-1β, and IL-18 in OC cells. Furthermore, the inhibitory effect of FAM72A knockdown was reversed by treating cells with mitochondrial inhibitors or by specifically knocking down PINK1. In vivo experiments confirmed that FAM72A promoted tumor growth by inhibiting the PINK1/Parkin pathway. Conclusively, FAM72A knockdown drives mitophagy and pyroptosis in OC by activating the PINK1/Parkin pathway, highlighting its potential as a therapeutic target for OC.

Indexed as

Gene Knockdown TechniquesMitophagyNeoplasm ProteinsOvarian NeoplasmsProtein KinasesPyroptosisSignal TransductionUbiquitin-Protein LigasesAnimalsCell Line, TumorFemaleHumansMiceMice, NudeMitochondriaPTEN-Induced Putative KinaseNeoplasm Proteinsparkin proteinProtein KinasesPTEN-Induced Putative KinaseUbiquitin-Protein LigasesFAM72AMitophagyOvarian cancerPINK1/Parkin pathwayPyroptosis

Identifiers

PMID42159844

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.