Evidence map›Paper›PMID 42159830›Full record

ArticleAdvanced biotechnology2026

Controllable nanotopography of lysine-branched self-assembling peptide hydrogels for tendon-bone insertion regeneration.

Xu Liu, Chenyu Wang, Xiao Zhao, Yi Xiao, Yuzhi Sun, Xin Zhang, Qingqiang Yao, Yilun Wu, Yi-Shen Zhu

Abstract read
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In one paragraph

Article in Advanced biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Xu LiuCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Chenyu WangCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Xiao ZhaoDepartment of Orthopaedic Surgery, Institute of Digital Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Yi XiaoCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China.
Yuzhi SunDepartment of Orthopaedic Surgery, Institute of Digital Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Xin ZhangDepartment of Orthopaedic Surgery, Nanjing First Hospital, Nanjing, 210006, China.
Qingqiang YaoDepartment of Orthopaedic Surgery, Institute of Digital Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Yilun WuCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China. yilun.wu@njtech.edu.cn.
Yi-Shen ZhuCollege of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, 211816, China. zhuyish@njtech.edu.cn.ORCID http://orcid.org/0000-0002-2616-8501

Funding

National Key Research and Development Program of China 2023YFB3813000National Natural Science Foundation of China 22305117Natural Science Foundation of Jiangsu Province BK20220336Science and Technology Project of Jiangsu Province BE2022718
6 · The paper itself

Abstract

Recent advances in tissue engineering have highlighted the critical roles of both mechanical and biochemical characteristics in tendon-bone insertion (TBI) regeneration. However, the influence of surface topography, particularly the development of biocompatible hydrogels with aligned nanotopographical structures while preserving intrinsic mechanical properties, remains insufficiently explored. Here, we engineered a lysine-branched self-assembling peptide hydrogels (Lys-SAPHs) to promote TBI healing. Compared with pristine SAPH, Lys-SAPHs exhibited distinctive aligned 3D groove-like topographies without compromising mechanical integrity or hemocompatibility. In vitro, Lys-SAPHs enhanced tendon stem cells (TSCs) and bone marrow mesenchymal stem cells (BMSCs) proliferation, migration, and tendonogenic differentiation, while promoting macrophage polarization toward a reparative M2 phenotype. In a rat TBI defect model, optimized Lys-SAPH (FEK17:FEK8 = 1:6) treatment facilitated superior tendon-bone regeneration, evidenced by reduced bone defect area on micro-CT, improved Achilles functional index (AFI), and increased fibrocartilage formation compared with SAPH and control groups. This study highlighted the critical role of nanotopography in directing stem cell fate and immune modulation and presented Lys-SAPHs as a versatile platform for designing next-generation self-assembling peptide hydrogels for tendon-bone repair and broader regenerative applications.

Indexed as

Lysine-branched self-assembling peptide hydrogelsMacrophage polarizationNanotopographyStem cell differentiationTendon-bone insertion regeneration

Identifiers

PMID42159830
PMCPMC13190967

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