Evidence map›Paper›PMID 42159823›Full record

ReviewHealth economics review2026

Cost-effectiveness of maternal and neonatal health interventions in Ethiopia: a systematic review and meta-analysis.

Akalu Duguma Sima, Endale Tamiru Burayu, Zelalem Banjaw Zegeye

Abstract readReview
In one paragraph

Review in Health economics review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Akalu Duguma SimaDepartment of Accounting and Finance, College of Business and Economics, Mattu University, Mattu, Southwest Ethiopia, Ethiopia. akeduguma@gmail.com.
Endale Tamiru BurayuDepartment of Midwifery, College of Health Science, Mattu University, Mattu, Southwest Ethiopia, Ethiopia. endalejesus88@gmail.com.ORCID http://orcid.org/0000-0001-8425-9527
Zelalem Banjaw ZegeyeDepartment of Biomedical Science, Faculty of Medical Sciences, Institute of Health Sciences, Jimma University, Jimma, Southwest Ethiopia, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite recent improvements in health service coverage, maternal and neonatal mortality remain major public health concerns in Ethiopia. Evidence regarding cost-effectiveness is crucial for prioritizing interventions within the Essential Health Services Package, particularly in resource-constrained settings.

objectiveThis study aims to systematically review and conduct a meta-analysis on the cost-effectiveness of maternal and neonatal health (MNH) interventions in Ethiopia.

methodsWe conducted a comprehensive search across multiple databases (PubMed/MEDLINE, Embase, the Cochrane Library, CINAHL, Scopus, Web of Science, African Journals Online; including the Ethiopian Journal of Health Development, Tufts Cost-Effectiveness Analysis Registry, and Google Scholar) from January 2000 to December 2024. A total of twelve studies were included in the qualitative synthesis and meta-analysis. A random-effects meta-analysis was performed for interventions with three or more comparable estimates utilizing the DerSimonian-Laird method.

resultsThe pooled incremental cost-effectiveness ratios (ICERs) showed high cost-effectiveness for key neonatal interventions: US$6.23 per DALY averted (95% CI: 4.22-8.23; I

conclusionNeonatal resuscitation, sepsis management, and antenatal care are cost-effective interventions (all pooled ICERs substantially below commonly referenced Ethiopian contextual benchmarks, such as around 1 × projected 2025 GDP per capita of ≈US$950-1,100 per DALY averted, though we note debates on GDP-based approaches and the importance of opportunity costs and affordability). Community-based scale-up in rural regions can optimize outcomes.

trial registrationPROSPERO registration number: CRD420251182108.

Indexed as

Cost-effectivenessDALYEthiopiaICERMaternal healthMeta-analysisNeonatal healthSystematic review

Identifiers

PMID42159823
PMCPMC13242135

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.