Evidence map›Paper›PMID 42159699›Full record

ArticleArchives of microbiology2026

Xanthoxylin as a quorum-sensing inhibitor of Aeromonas hydrophila with promising therapeutic effects.

Shengping Li, Shun Zhou, Xiaohui Ai, Jing Dong

Abstract read
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In one paragraph

Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shengping LiNational Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China.
Shun ZhouYangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, 430223, China.
Xiaohui AiNational Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China.
Jing DongYangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, 430223, China. dongjing@yfi.ac.cn.

Funding

Central Public-interest Scientific Institution Basal Research Fund, Chinese Academy of Fishery Sciences 2023TD47Technological Innovation project of Hubei Province 2024BBB072
6 · The paper itself

Abstract

Aeromonas hydrophila (A. hydrophila) is widely spread in different aquatic environments and still poses a serious threat to the health of aquatic animals. Nevertheless, with the emergence of drug-resistant A. hydrophila, antibiotics have shown limited efficacy as primary therapeutic agents, and novel treatment strategies are urgently needed. The increasing understanding of anti-virulence and anti-quorum-sensing (QS) strategies offers new hope for drug discovery against A. hydrophila infections, which aim not to inhibit or kill bacteria but to reduce pathogenicity by reducing the production or activity of virulence factors. Here, xanthoxylin was screened out, and some tests were conducted on virulence phenotypes and therapeutic effects; the results demonstrated that xanthoxylin lacked anti-A. hydrophila effect could reduce the levels of QS-mediated virulence factors and the transcription of the aerA, ahyR, and ahyI genes. Further therapeutic results showed that xanthoxylin could protect A549 cells from cytotoxicity induced by aerolysin and improve the survival rate of crucian carp (Carassius auratus gibelio) challenged with A. hydrophila. Therefore, xanthoxylin could be a potential QS inhibitor for controlling A. hydrophila infections in aquaculture.

Indexed as

Aeromonas hydrophilaAnti-Bacterial AgentsFish DiseasesGram-Negative Bacterial InfectionsQuorum SensingAnimalsBacterial ProteinsHumansVirulenceVirulence FactorsAnti-Bacterial AgentsBacterial ProteinsVirulence FactorsAeromonas hydrophilaAlternative therapeuticsQuorum sensingVirulenceXanthoxylin

Identifiers

PMID42159699

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.