Evidence map›Paper›PMID 42159697›Full record

ArticleThe Journal of membrane biology2026

Fluorescence Lifetime Spectroscopy Reveals Distinct Allosteric Mechanisms of SERCA Inhibitors.

Jaroslava Šeflová, Carlos Cruz-Cortés, Seth L Robia, L Michel Espinoza-Fonseca

Abstract read
In one paragraph

Article in The Journal of membrane biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jaroslava ŠeflováDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, 60153, USA. jseflova@luc.edu.
Carlos Cruz-CortésDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Seth L RobiaDepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, 60153, USA.
L Michel Espinoza-FonsecaDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, 48109, USA. lmef@umich.edu.

Funding

Structural Determinants of Calcium Pump RegulationR01HL092321 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia · 2008 to 2026
$8.9M
Hit-to-lead optimization for heart failure drug discoveryR01HL148068 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ESPINOZA-FONSECA, LENNANE MICHEL, HERRON, TODD JOSEPH · 2019 to 2022
$2.9M
NHLBI NIH HHS R01HL092321NHLBI NIH HHS R01HL148068
6 · The paper itself

Abstract

We recently developed a time-correlated single photon counting (TCSPC) spectroscopy approach to investigate the activation mechanisms of the calcium pump SERCA (sarcoplasmic reticulum Ca

Indexed as

Enzyme InhibitorsIndolesSarcoplasmic Reticulum Calcium-Transporting ATPasesThapsigarginAdenosine TriphosphateAllosteric RegulationAnimalsCalciumProtein ConformationSpectrometry, FluorescenceAdenosine TriphosphateCalciumcyclopiazonic acidEnzyme InhibitorsIndolesSarcoplasmic Reticulum Calcium-Transporting ATPasesThapsigarginAllosteric modulationFluorescence lifetime spectroscopyInhibitionSERCA

Identifiers

PMID42159697
PMCPMC13190474

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.