Evidence map›Paper›PMID 42159676›Full record

ArticleJournal of anesthesia2026

Effect of flurbiprofen on intraoperative nausea and vomiting during cesarean delivery: a single-center retrospective cohort study.

Taiga Nagase, Kyosuke Takahashi, Miho Shishii, Hiroaki Kondo, Tomoe Fujita, Shunsuke Hyuga

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of anesthesia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Taiga NagaseDivision of Obstetric Anesthesia, Center for Perinatal Care, Child Health and Development, Kitasato University Hospital, 1-15-1 Kitasato, Minami-Ku, Sagamihara City, Kanagawa, 252-0375, Japan.
Kyosuke TakahashiDepartment of Anesthesiology, Institute of Science Tokyo Hospital, 1-5-45 Yushima, Bunkyo-Ku, Tokyo, Japan.
Miho ShishiiDivision of Obstetric Anesthesia, Center for Perinatal Care, Child Health and Development, Kitasato University Hospital, 1-15-1 Kitasato, Minami-Ku, Sagamihara City, Kanagawa, 252-0375, Japan.
Hiroaki KondoDivision of Obstetric Anesthesia, Center for Perinatal Care, Child Health and Development, Kitasato University Hospital, 1-15-1 Kitasato, Minami-Ku, Sagamihara City, Kanagawa, 252-0375, Japan.
Tomoe FujitaDivision of Obstetric Anesthesia, Center for Perinatal Care, Child Health and Development, Kitasato University Hospital, 1-15-1 Kitasato, Minami-Ku, Sagamihara City, Kanagawa, 252-0375, Japan.
Shunsuke HyugaDivision of Obstetric Anesthesia, Center for Perinatal Care, Child Health and Development, Kitasato University Hospital, 1-15-1 Kitasato, Minami-Ku, Sagamihara City, Kanagawa, 252-0375, Japan. shyuga@kitasato-u.ac.jp.ORCID http://orcid.org/0000-0002-1095-8066

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIntraoperative nausea and vomiting are common during cesarean delivery under neuraxial anesthesia, and peritoneal traction is a major trigger. Flurbiprofen, a non-steroidal anti-inflammatory drug used for multimodal analgesia, is typically administered toward the end of surgery; whether earlier intraoperative administration is associated with reduced intraoperative nausea and vomiting remains unclear.

methodsWe conducted a retrospective cohort study at a single tertiary university hospital in Japan from October 1, 2021 to September 30, 2025. Parturients undergoing cesarean delivery under neuraxial anesthesia were classified as an early group (intravenous flurbiprofen administered after umbilical cord clamping and by the start of peritoneal closure) or a non-early group (administered after the start of peritoneal closure or not administered intraoperatively). The primary outcome was intraoperative antiemetic use, pre-specified as a surrogate for intraoperative nausea and vomiting. Adjusted odds ratios were estimated using multivariable logistic regression with pre-specified sensitivity analyses.

resultsA total of 1398 parturients were included (early, n = 1062; non-early, n = 336). Intraoperative antiemetic use occurred in 172/1,062 (16.2%) and 91/336 (27.1%), respectively, corresponding to an absolute risk difference of - 10.9 percentage points. Early flurbiprofen administration was associated with lower odds of intraoperative antiemetic use (adjusted odds ratio 0.54; 95% confidence interval 0.41 to 0.73; P < 0.001), with consistent findings across sensitivity analyses.

conclusionEarly intraoperative flurbiprofen administration after umbilical cord clamping was associated with lower intraoperative antiemetic use during cesarean delivery under neuraxial anesthesia, suggesting that the timing of routine non-steroidal anti-inflammatory drug administration may be relevant to intraoperative nausea and vomiting management.

Indexed as

Cesarean deliveryFlurbiprofenIntraoperative nausea and vomitingMesenteric traction syndromeNon-steroidal anti-inflammatory drug

Identifiers

PMID42159676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.