ArticlePsychopharmacology2026
Transcriptional profiling reveals brain region-specific changes in gene expression induced by chronic unpredictable mild stress between stress-susceptible and stress-resilient mice.
Article in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Maternal Social Support Reshapes the Offspring Brain Transcriptome to Buffer Prenatal Stress in Mice.Research square · 2026Article
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7 authors.
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Abstract
rationaleDepression is a common psychiatric disorder characterized mainly by low mood, anhedonia, and sleep disturbances. In severe cases, it can lead to suicidal tendencies and behaviors. Chronic stress can induce depressive symptoms in some individuals, while others do not respond from stressful experiences, which may represent an intrinsic mechanism underlying resistance to external stressors. The molecular mechanism underlying this resilience remains elusive.
objectivesIn this study, the molecular differences in the brains between chronic unpredictable mild stress (CUMS) induced depression-like behaviors (CUMS-susceptible) and resilience behaviors (CUMS-resilience) mice were analyzed based on transcriptome sequencing datasets acquired in our prior published work.
methodsWe performed GO and KEGG functional analyses of differentially expressed genes (DEGs) in distinct brain regions and validated some DEGs in vivo.
resultsThe results showed significant molecular differences in the ventral tegmental area (VTA), amygdala, nucleus accumbens (NAc), and medial prefrontal cortex (mPFC) of CUMS-susceptible and CUMS-resilience mice. Additionally, analysis of DEGs identified four DEGs (Fgfr3, Prodh, Slco1a4, and Gm15446) in the VTA, amygdala, NAc, and mPFC. This suggested that the molecular differences between CUMS-susceptible and CUMS-resilience mice were region-specific.
conclusionsTaken together, our studies have revealed a transcription network between depression-like behaviors and resilience behaviors induced by CUMS, and provide new fundamental insights and potential targets for antidepressants discovery.
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