ArticleMolecular genetics and genomics : MGG2026
Genome comparison of the bacteria in Mycobacterium avium complex (MAC) reveals the role of translational selection in shaping codon usage patterns.
Article in Molecular genetics and genomics : MGG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The Mycobacterium avium complex (MAC) houses several pathogens that cause diseases in humans, ruminants, and birds. They are widely distributed in soils and water worldwide. In immunocompromised humans, MAC is responsible for nodular bronchiectasis and fibrocavitary lung diseases. The treatment of lung diseases induced by MAC remains difficult owing to antibiotic intolerance and disease recurrence. In this study, we compared the genome sequences of 90 complete MAC genomes and explored the factors shaping codon usage bias in the bacteria within MAC. Additionally, we studied the relationship between codon bias and pathogenic adaptation. The genome sizes ranged from 4.7 to 6.5 Mb. Variation in the mobile genetic elements and the number of CRISPR candidates was observed amongst the bacteria within MAC. Synonymous codon usage analysis divulged variations among subspecies, high codon usage bias, substantial heterogeneity in codon usage patterns, and moderate use of optimal codons. High GC3 content and elevated levels of CAI (a metric for gene expression levels) in all probability assisted the bacteria within MAC in adjusting to different host environments. Translational selection pressure prevailed over compositional bias and mutational selection in these organisms. Our analysis revealed differences in the tRNA content amongst the bacteria in MAC. The translational selective pressure enabled the adaptation of these pathogenic bacteria to competitive pressure in diverse environments and niches by maintaining a lesser number of tRNAs and lower tAI values.
Indexed as
Identifiers
42159624What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.