ArticleMicrobiology spectrum2026
Effects of mutations conferring pyrazinamide resistance among multidrug-resistant tuberculosis isolates from China.
Xiang-Long Bo, Ma-Chao Li, Hao Hang, Shi-Qiang Lin, Hai-Can Liu, Cheng Qian, Gui-Lian Li, Xiu-Qin Zhao, Kang-Lin Wan, Li-Li Zhao
Abstract read
In one paragraphArticle in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Xiang-Long Bo *National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.ORCID 0009-0009-0738-2367 Ma-Chao Li *National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Hao Hang *National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Shi-Qiang LinCollege of Life Science, Fujian Agriculture and Forestry University, Fuzhou, China.
Hai-Can LiuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Cheng QianBeijing Center for Disease Control and Prevention, Beijing, China.
Gui-Lian LiNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Xiu-Qin ZhaoNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Kang-Lin WanNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Li-Li ZhaoNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.ORCID 0000-0002-6729-2998 Funding
Naitonal key program of mega infectious diseases 2018ZX10302302Nation key research and development program of china 2023YFC2307204
6 · The paper itselfAbstract
To investigate the effects of mutations on pyrazinamide (PZA)-associated regions, including IMPORTANCE: In this study, we systematically investigated the mutations in pyrazinamide (PZA)-resistance-associated genes, including pncA, rpsA, panD, and clpC1, among the multidrug-resistant tuberculosis (MDR-TB) isolates from China, and their effects on the PZA resistance. This study is essential for comprehensively understanding the association between the phenotypic susceptibility to PZA and the mutation patterns in clinical MDR-TB isolates in China and is helpful for designing reliable and rapid molecular diagnostic assays for PZA resistance.
Indexed as
Antitubercular AgentsDrug Resistance, Multiple, BacterialMutationMycobacterium tuberculosisPyrazinamideTuberculosis, Multidrug-ResistantAmidohydrolasesChinaGenotypeHumansMicrobial Sensitivity TestsSequence Analysis, DNAAmidohydrolasesAntitubercular AgentsPncA protein, Mycobacterium tuberculosisPyrazinamidegenemultidrug-resistant tuberculosismutationpyrazinamide resistance
Identifiers
PMID42159504
PMCPMC13340127
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