ReviewChemical reviews2026
Peripheral Myelin Protein-22 and Its Prominence in Charcot-Marie-Tooth Disease.
Review in Chemical reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Charcot-Marie-Tooth disease (CMT) is an often-debilitating peripheral neuropathy that is a top-10 most prevalent human genetic disorder. However, there is currently no effective treatment. Over half of diagnosed CMT cases in western populations are caused by genetic variations that alter the expression levels or sequence of peripheral myelin protein 22 (PMP22). PMP22 is a tetraspan membrane glycoprotein that is most highly expressed in Schwann cells (SCs) of the peripheral nervous system (PNS) under conditions of myelination, where it plays multiple important roles. These functions are reduced in humans with only a single
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