Trial reportCritical care medicine2026
Effects of the ABCDEF Bundle on Delirium, Function, and Quality of Life in Australian ICU Patients: A Pragmatic Randomized Controlled Trial.
Trial report in Critical care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo test whether the ABCDEF bundle, compared with usual care, decreases delirium incidence and duration, improves functional status in the ICU, and enhances 90-day post-ICU discharge quality of life in critically ill Australian adults.
designSingle-center, pragmatic, randomized controlled trial.
settingEight-bed medical/surgical ICU in a metropolitan Australian hospital. PATIENTS: Adult patients expected to remain in ICU for at least 48 hours.
interventionsABCDEF bundle or usual care. MEASUREMENTS AND MAIN
resultsComplete ABCDEF bundle adherence was achieved in 50% of patients each study day. The primary outcome, cumulative incidence of delirium (measured with the Confusion Assessment Method for ICU), was similar between groups (ABCDEF, 37.9%; usual care, 36.4%; odds ratio, 1.1; 95% CI, 0.5-2.2; p = 0.86), as was median delirium duration (ABCDEF, 2.0 d; interquartile range [IQR], 1.3-3.5 d; usual care, 2.5 d; IQR, 1.0-4.4 d; mean difference, -0.4 d; 95% CI, -1.6 to 0.8 d; p = 0.53). Median functional scores at ICU discharge (measured with the Functional Independence Measure) were 55.0 (IQR, 37.0-67.3) in the ABCDEF group and 53.0 (IQR, 43.8-62.5) in the usual care group (mean difference, 0.0; 95% CI, -7.7 to 7.6; p = 0.83). At 90 days post-ICU discharge, the ABCDEF bundle group reported higher scores in the "usual activities" domain ( p < 0.001) (measured with the EuroQol 5D five-level questionnaire), with no differences in other domains.
conclusionsIn adult ICU patients, the ABCDEF bundle, compared with usual care, did not reduce the cumulative incidence or duration of delirium. While no effect was observed on the primary outcomes, higher scores in the "usual activities" quality of life domain suggest potential long-term benefits that warrant further investigation.
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