ArticleInvestigative ophthalmology & visual science2026
Aging of Nonhuman Primate Eyes Is Sexually Dimorphic.
Article in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To characterize sex-specific and offspring number-associated patterns of ocular aging in Macaca fascicularis. Methods: Comprehensive ophthalmic examinations were performed on 94 adult macaques (47 males, 47 females). Ocular biometry (lens thickness [LT], anterior chamber depth [ACD], axial length), nuclear lens density (NLD), macula retinal thickness, and retinal nerve fiber layer thickness (RNFLT) were assessed using IOLMaster and swept-source optical coherence tomography. Cataract and drusen were diagnosed using clinical imaging criteria. Sex-specific age associations were examined using correlation. Offspring number analyses included 16 females and 24 males with confirmed reproductive records. Results: Females and males differed significantly in ocular dimensions, with females showing smaller eyes and thinner retinas. Cataract prevalence was significantly higher in females compared to males (19.2% vs. 4.3%, P = 0.0286), whereas drusen prevalence was similar between sexes (17.0% in females vs. 14.9% in males). Although NLD and LT increased and ACD decreased with age in both sexes, aging slopes were consistently steeper in females. Increasing offspring number was associated with significant reductions in RNFLT in females, independent of age, while lens-related parameters showed no significant association with offspring number in either sex. Conclusions: Female macaques exhibit accelerated lens aging and increased cataract susceptibility, mirroring patterns observed in human populations. Offspring number selectively contributes to neuroretinal thinning, suggesting a reproductive influence on retinal decline that is distinct from lens aging. These findings highlight the importance of considering sex and reproductive history in NHP-based ocular aging studies and provide biological insights relevant to human age-related eye disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.