Observational studyInvestigative ophthalmology & visual science2026
Intrapapillary Damage and Its Functional Association in Normal Tension Glaucomatous Eyes With and Without Peripapillary Intrachoroidal Cavitation.
Observational study in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Purpose: To compare optic nerve head (ONH) structure, visual field (VF) characteristics, and structure-function relationships including intrapapillary structural changes between normal tension glaucomatous (NTG) eyes with and without peripapillary intrachoroidal cavitation (PICC). Methods: This cross-sectional observational study enrolled 94 NTG eyes with PICC (NTG + PICC), 188 NTG eyes without PICC (NTG - PICC) matched for age, axial length, and VF severity, and 30 healthy eyes. Bruch's membrane opening (BMO) and scleral flange opening (SFO) were identified on ONH-centered OCT images. SFO-minimum rim width (SFO-MRW), the shortest distance between the SFO and prelaminar tissue surface, was used to evaluate focal intrapapillary tissue thinning. ONH structure, sectoral Humphrey 24-2 VF sensitivity (VFS), circumpapillary retinal nerve fiber layer thickness and SFO-MRW were compared among groups. Multivariable linear regression models were applied to identify factors associated with sectoral VFS. Results: NTG + PICC showed significantly larger BMO and SFO areas and greater SFO/BMO offset magnitude compared with NTG - PICC and healthy eyes (all P < 0.001). Despite comparable circumpapillary retinal nerve fiber layer thickness and VF severity, NTG + PICC had worse temporal VFS (P = 0.006) and a thinner temporal SFO-MRW (P = 0.002). In the best-fit multivariable model, worse temporal VFS in NTG + PICC was significantly associated with thinner SFO-MRW, larger BMO area and smaller SFO area (all P < 0.05). Conclusions: NTG + PICC exhibited more pronounced myopia-associated ONH remodeling and temporal intrapapillary thinning compared with NTG - PICC, and these changes were associated with worse central VFS. These findings suggest that focal intrapapillary thinning at the peripapillary scleral edge is a potential structural biomarker that complements conventional RNFL-based evaluation in eyes with highly myopic changes.
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