Evidence map›Paper›PMID 42159296›Full record

ArticleProtein science : a publication of the Protein Society2026

Omega-3 DHA as a blank canvas: A molecular approximation to how lipid mediators modulate LGR6 in inflammation resolution.

Álex Pérez-Sánchez, Mireia Garcia-Viloca, Àngels González-Lafont, José M Lluch

Abstract read
In one paragraph

Article in Protein science : a publication of the Protein Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Álex Pérez-SánchezDepartament de Química, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0003-3636-3885
Mireia Garcia-VilocaDepartament de Química, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0001-5415-0248
Àngels González-LafontDepartament de Química, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0003-0729-2483
José M LluchDepartament de Química, Universitat Autònoma de Barcelona, Barcelona, Spain.ORCID 0000-0002-7536-1869

Funding

Ministerio de Ciencia, Innovación y Universidades PID2023-147140NBI00Ministerio de Ciencia, Innovación y Universidades PRE2021-098929
6 · The paper itself

Abstract

The leucine-rich repeat-containing G protein-coupled receptor 6 (LGR6) has a potential role in inflammation resolution and different cancer processes. In this study, we employed computational techniques, including molecular docking and molecular dynamics simulations of mammalian membrane-embeded systems, to understand the activation mechanism of LGR6 upon binding of the specialized pro-resolving lipid mediator maresin 1. Additionally, we investigated the interaction and the dynamics of other relevant lipid mediators (leukotriene B

Indexed as

Docosahexaenoic AcidsInflammation MediatorsReceptors, G-Protein-CoupledAllosteric RegulationHumansInflammationLeukotriene B4Molecular Dynamics SimulationProtein BindingProtein Conformation7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acidDocosahexaenoic AcidsInflammation MediatorsLeukotriene B4LGR6 protein, humanprotectin D1Receptors, G-Protein-CoupledAlphaFolddocosahexaenoic acidGPCRsinflammationleukotriene B4LGR6lipid mediatorsmaresin 1molecular dynamicsomega‐3 fatty acidsprotectin D1

Identifiers

PMID42159296
PMCPMC13240443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.