ReviewChemical reviews2026
Mechanochemical Methods for Amide Bond Formation.
Review in Chemical reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mechanochemical Amidation Mediated by 1,1'-Oxalyldiimidazole for the Synthesis of Agrochemicals.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mechanochemical methodologies are reshaping synthetic organic chemistry by enhancing practicality and reducing environmental impact. This review presents a comprehensive account of mechanochemical methods for amide bond formation, arguably the most developed and industrially relevant area within mechanochemical organic synthesis. Covering literature from early contributions to the present (September 2025), the review organization follows key substrate classes and methodological strategies: amide bond formation via coupling of carboxylic acids or their activated derivatives with amines (Section 2), followed by unconventional approaches (Section 3) employing carboxylic acid and amine surrogates, redox chemistry, rearrangements, and transition metal-mediated reactions leading to amide products through alternative bond-forming pathways. Mechanoenzymatic transformations are treated separately (Section 4), with stereochemistry-related issues, such as the preservation of enantiomeric purity, discussed in Section 5. Section 6 highlights the use of amide bond formation as a model system for probing mechanochemical driving forces. Special attention is given to scalability and successful scale-up examples, alignment with green chemistry principles, limitations, unexplored areas, and challenges requiring further development. This review is intended as an accessible and thorough resource for synthetic chemists in both academia and industry, including those newly exploring the field of mechanochemistry, and it provides practical guidance for process optimization and scale-up.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.