Evidence map›Paper›PMID 42158894›Full record

ArticleFood science & nutrition2026

Cocoa Bean Shell as a Functional Food By-Product: Antioxidant Potential and Toxicological Thresholds in

Fernanda Dos Santos Trombini, Nathália Cardoso de Afonso Bonotto, Maria Eduarda Chelotti, Débora Luísa Pulcinelli, Caroline Prado Rehbein, Eliana Jardim Fernandes, Elize Musachio, Vitória Azzolin, Euler Ribeiro Filho, Maria Denise Schimith and 3 more

Abstract read
In one paragraph

Article in Food science & nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fernanda Dos Santos TrombiniPostgraduate Program of Nursing, Federal University of Santa Maria Santa Maria-RS Brazil.ORCID https://orcid.org/0000-0002-3999-9101
Nathália Cardoso de Afonso BonottoPostgraduate of Pharmacology, Federal University of Santa Maria Santa Maria Brazil.
Maria Eduarda ChelottiPostgraduate of Pharmacology, Federal University of Santa Maria Santa Maria Brazil.
Débora Luísa PulcinelliBiogenomics Laboratory, Federal University of Santa Maria Santa Maria Brazil.
Caroline Prado RehbeinBiogenomics Laboratory, Federal University of Santa Maria Santa Maria Brazil.
Eliana Jardim FernandesPostgraduate Program in Biochemistry, Federal University of Pampa Uruguaiana Brazil.ORCID https://orcid.org/0000-0002-9451-674X
Elize MusachioPostgraduate Program of Nursing, Federal University of Santa Maria Santa Maria-RS Brazil.ORCID https://orcid.org/0000-0002-2577-2379
Vitória AzzolinOpen Third-Age University Foundation, Amazonas Manaus Brazil.
Euler Ribeiro FilhoAmazonas State University Manaus Brazil.
Maria Denise SchimithPostgraduate Program of Nursing, Federal University of Santa Maria Santa Maria-RS Brazil.
Verônica Farina AzzolinOpen Third-Age University Foundation, Amazonas Manaus Brazil.
Ivana Beatrice Mânica da CruzOpen Third-Age University Foundation, Amazonas Manaus Brazil.
Fernanda BarbisanPostgraduate of Pharmacology, Federal University of Santa Maria Santa Maria Brazil.ORCID https://orcid.org/0000-0002-2960-7047

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Agro-industrial fruit processing generates by-products with potential for the development of health-promoting supplements. One such by-product is the cocoa bean shell, a residue from chocolate production that is rich in polyphenols and other bioactive compounds. This study evaluated the chemical composition and biological effects of a combined hot and cold aqueous extract of cocoa bean shell (Cascau), using

Indexed as

behavioral assaysbioactive compoundsdose‐dependent toxicityDrosophila melanogasteroxidative stressphenolic compoundspolyphenolsTheobroma cacao

Identifiers

PMID42158894
PMCPMC13181427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.