Evidence map›Paper›PMID 42158858›Full record

ArticleFrontiers in immunology2026

Exhausted CD4

Hayato Nakamura, Tomohiro Okagawa, Malik Hamaïdia, Wisa Tiyamanee, Mari Ikehata, Minagi Hirose, Maho Inoue, Luc Willems, Keisuke Maezono, Passawat Thammahakin and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hayato NakamuraDepartment of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Tomohiro OkagawaDepartment of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Malik HamaïdiaMolecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liège, Liège, Belgium.
Wisa TiyamaneeDepartment of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Mari IkehataDepartment of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Minagi HiroseDepartment of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Maho InoueDepartment of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Luc WillemsMolecular and Cellular Epigenetics, Interdisciplinary Cluster for Applied Genoproteomics (GIGA), University of Liège, Liège, Belgium.
Keisuke MaezonoLaboratory of Public Health, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Passawat ThammahakinLaboratory of Public Health, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Shintaro KobayashiLaboratory of Public Health, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Yukinari KatoDepartment of Antibody Drug Development, Tohoku University Graduate School of Medicine., Sendai, Japan.
Yasuhiko SuzukiInstitute for Vaccine Research and Development (HU-IVReD), Hokkaido University, Sapporo, Japan.
Naoya MaekawaDepartment of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Shiro MurataDepartment of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Kazuhiko OhashiDepartment of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Satoru KonnaiDepartment of Disease Control, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In enzootic bovine leukosis (EBL), a B-cell lymphoma caused by bovine leukemia virus (BLV) infection, immune remodeling within tumor-affected lymph nodes is currently poorly understood. Here, we analyzed chemokine production and macrophage phenotypes in tumor-affected lymph nodes in EBL, focusing on CCL4. Intracellular cytokine staining revealed that, compared with healthy lymph nodes, EBL tumor-affected lymph nodes showed increased proportions of CCL4 expressing cells, particularly among CD4

Indexed as

CD4-Positive T-LymphocytesEnzootic Bovine LeukosisLeukemia Virus, BovineMacrophagesAnimalsCattleLymph NodesT-Cell ExhaustionB-cell lymphomaBLVCCL4EBLmacrophageTAM

Identifiers

PMID42158858
PMCPMC13180550

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.