ArticleFrontiers in immunology2026
Precuneus hyperexcitability mediates inflammatory-driven pain hypersensitivity following sleep disruption: a multimodal neuroimaging study.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sleep disruption(SD) has been shown to amplify inflammatory signaling and promote pain hypersensitivity, but how inflammation interacts with brain functional alterations to drive pain sensitization remains unclear. This study therefore aims to investigate inflammatory associated pain hypersensitivity induced by SD and characterize neural correlates for mediating neuroimmune-pain interactions. Materials and methods: This study employed two complementary designs: 1) A experimental design comparing forced awakening (FA) and uninterrupted sleep (US) groups, with polysomnography (PSG), task-fMRI, structural MRI, inflammatory cytokines, and quantitative sensory testing post-intervention; 2) A longitudinal cohort of chronic pain patients assessed pre- and 3-months postoperatively using neuroimaging, clinical pain metrics, and sleep quality indices (PSQI). Mass univariate analyses were performed to reveal differences in pain-elicited brain response between FA and US group. Structural and functional metrics were analyses within resultant brain regions using patient cohort. Multivariate correlations and mediation models were performed to test neuroimmune interactions. Results: FA subjects exhibited reduced total/slow-wave sleep, elevated IL-6, and lowered pain-thresholds versus US. Task-fMRI revealed hyperactivation in the precuneus and middle temporal gyrus during pain processing after FA. Serum IL-6 inversely correlated with pain thresholds and positively with precuneus activation. Mediation analysis demonstrated a mediating effect of precuneus hyperexcitability on the IL-6-pain hypersensitivity relationship. Longitudinal data from patient cohort complemented these findings, showing aberrant precuneus normalization correlated with improvement in pain and sleep quality. Conclusion: Across experimental and clinical cohorts, we identified the precuneus as a cortical hub linking sleep disruption, inflammation, and pain hypersensitivity, thereby revealing a novel neuroimmune pathway for sleep-related pain amplification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.