Evidence map›Paper›PMID 42158852›Full record

ArticleFrontiers in oncology2025

Ultra-sensitive detection of mutant

Madison Cox, Amy Wells, Dominic Vitello, Larissa Masnyk, Lauren M Janczewski, Vishvetha Rengaraju, Chengwei Peng, John Abad, Qiang Zhang, Shidong Jia and 2 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Integrative in silico and clinical validation of urinary lncRNAs (SNHG7 & LINC00675) and β-catenin mRNA as molecular markers for early bladder cancer detection.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Article
  2. High-Sensitivity ctDNA Analysis Uncovers Relevant Signals Missed by NGS in Pancreatic Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  3. Exploring tyrosine kinase inhibitors for HER2-positive breast cancer: comprehensive review on a complete pharmacology-molecular mechanisms, safety profiles, and insights from preclinical and clinical studies.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Madison CoxDepartment of Surgery, Division of Surgical Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Amy WellsDepartment of Surgery, Division of Surgical Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Dominic VitelloDepartment of Surgery, Division of Surgical Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Larissa MasnykDepartment of Surgery, Division of Surgical Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Lauren M JanczewskiDepartment of Surgery, Division of Surgical Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Vishvetha RengarajuDepartment of Surgery, Division of Surgical Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Chengwei PengNorthwestern Cancer Centers, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
John AbadDepartment of Surgery, Division of Surgical Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Qiang ZhangRobert H. Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Shidong JiaPredicine, Inc., Hayward, CA, United States.
Pan DuPredicine, Inc., Hayward, CA, United States.
Akhil ChawlaDepartment of Surgery, Division of Surgical Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.

Funding

National and Institutional Leadership and Support of NCI-Sponsored Clinical Trial Research as a Surgical OncologistR50CA293523 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Akhil Chawla · 2024 to 2026
$272k
NCI NIH HHS R50 CA293523
6 · The paper itself

Abstract

Introduction: Over 90% of pancreatic adenocarcinoma (PDAC) has a Methods: Plasma samples were collected from 45 patients with non-metastatic PDAC prior to treatment start. Baseline ctDNA was analyzed for Results: Standard depth sequencing identified pathogenic Conclusion: Ultra-deep sequencing demonstrates robust detection of pertinent

Indexed as

biomarkercirculating tumor DNAKRASneoadjuvant chemotherapynext generation sequencingpancreatic cancerultra-deep sequencing

Identifiers

PMID42158852
PMCPMC13180577

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.