ReviewBrain communications2026
Recent developments in Friedreich's ataxia: a state-of-the-art review.
Review in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Friedreich's Ataxia (FRDA) is a progressive disorder, which is autosomal recessive. It is one of the most common inherited ataxias in Europe, the Middle East, South Asia and North Africa. It is a life limiting condition, the time of onset until death is on average 36 years. A lack of certainty about specific phenotypic changes, has meant that, until recently, there have been no medications licensed for use in FRDA. Over the last 5 years, the development of omaveloxolone has stimulated increasing research into the mechanistic understanding of FRDA. We have conducted a critical review of all the studies published between 1999 and December 2024. The free text search terms were ((Friedreich's Ataxia) OR (FRDA) OR (FRDA) OR (inherited ataxias)) AND ((recent developments) OR (new developments) OR (new treatments) OR (phenotype)). We identified common themes, for example cellular phenotypical changes, such as mitochondrial and iron dysregulation and common medications that have been trialled. We have analysed the relevant, available studies (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.