ArticlePolish journal of radiology2026
Quantitative myocardial hypoperfusion on coronary CTA: correlation with left atrial and left ventricular functional parameters.
Article in Polish journal of radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To investigate the association between myocardial hypodensity on standard coronary computed tomography angiography (CCTA) and echocardiographic diastolic dysfunction (DD) grade, and to evaluate correlations between hypodensity percentage and CT-derived left atrium (LA) and left ventricular (LV) functional parameters. Material and methods: This retrospective study included 156 patients (mean age 47.9 ± 11.4 years, 86 men) who underwent CCTA for suspected coronary artery disease and had comprehensive echocardiographic data. Myocardial hypodensity was quantified as the percentage of LV myocardium with attenuation < 46 HU using semi-automated, patient-specific attenuation mapping. Left atrial ejection fraction (LAEF) and volumes were derived from multiphase CCTA reconstructions, and echocardiographic diastolic dysfunction was classified as per American Society of Echocardiography and the European Association of Cardiovascular Imaging (ASE/EACVI) 2016 guidelines. Coronary artery disease (CAD) severity (CAD-RADS 2.0) and cardiovascular risk (SMART score) were also recorded. Correlation, ROC, and multivariate regression analyses were performed; a data-driven LAEF threshold was used to stratify impaired atrial function. Results: Hypodensity percentage correlated inversely with LAEF ( Conclusions: Quantitative myocardial hypodensity on CCTA correlates with subclinical diastolic dysfunction and LA functional impairment. These findings support the potential of incorporating perfusion metrics into routine CCTA workflows to improve early diastolic assessment.
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