ReviewInternational journal of medical sciences2026
The Role of Macrophages in Acute Pancreatitis: From Inflammatory Drivers to Therapeutic Targets.
Review in International journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Single-cell RNA sequencing reveals PANoptosis signatures of acinar cells, macrophages, and neutrophils during injury and repair in acute pancreatitis.Frontiers in cell and developmental biology · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute pancreatitis (AP) involves activation of the innate immune system and an imbalanced inflammatory response. Both pancreatic and systemic inflammation associated with AP are mediated by macrophages. This review summarizes research on macrophage functions in AP pathogenesis and treatment. Relevant studies investigating macrophage activation, phenotypes, autophagy, and their roles in local and systemic inflammation were analyzed. During AP, macrophages initially adopt a pro-inflammatory phenotype to amplify inflammation. Macrophages located in tissues including the pancreas, adipose tissue, liver, lung, and spleen play a role in this process. As the disease progresses, they transition to an M2 phenotype to promote resolution. Macrophage-centered modulation of the innate immune response represents a promising therapeutic strategy. However, further exploration of macrophage interactions with other immune cells and pancreatic acinar cells is still needed. Targeting specific macrophage functions may improve AP management, which is the focus of this review.
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Registered trials
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