ArticleCureus2026
The Use of Amantadine in a Nontraumatic Disorder of Consciousness: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Disorders of consciousness (DoC) are among the most challenging conditions encountered in clinical practice, often complicating both diagnosis and management. Although amantadine has demonstrated benefit in facilitating recovery in patients with traumatic brain injury (TBI)-related DoC, its impact on nontraumatic causes has not been well established. We describe the case of an elderly patient with persistent encephalopathy following an ischemic stroke who experienced marked neurological improvement shortly after initiation of amantadine therapy. This case highlights the potential role of amantadine as a therapeutic option in non-TBI-related disorders of consciousness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.